ArticleFrontiers in immunology2026
Balancing inflammatory signaling in hematopoiesis: roles of MIRC11 and miR-146a.
Article in Frontiers in immunology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Introduction: Inflammatory signaling regulates hematopoietic stem and progenitor cell (HSPC) function, but mechanisms that maintain inflammatory signaling within a physiological range remain incompletely understood. MicroRNAs (miRNAs) are important regulators of immune signaling pathways. In this report we hypothesized that MIRC11 miRNAs (miR-23a, miR-24-2, and miR-27a) and miR-146a which oppositely regulate NF-κB activity, function to fine-tune inflammatory responses in hematopoietic cells. Methods: Inflammatory gene expression in Results: RNA sequencing revealed reduced activation of inflammatory pathways including interferon, TNF, IL-6, and TLR signaling in mmu-MIRC11-deficient HSPCs. Double knockout mice were viable and exhibited modest changes in the lineage skewing observed in Discussion: These findings demonstrate that MIRC11 promotes inflammatory signaling in hematopoietic cells and that interactions between MIRC11 and miR-146a regulate inflammatory gene expression in a context-dependent manner. Together, these results highlight the complexity of miRNA-mediated control of immune signaling and suggest that coordinated manipulation of miRNA pathways may enable selective modulation of inflammatory responses.
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