ArticleFrontiers in immunology2026
Clinical features of Q fever confirmed by plasma metagenomic next-generation sequencing.
Article in Frontiers in immunology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: The clinical features of acute Q fever and their link to transient autoantibodies remain poorly defined. We characterized 44 plasma mNGS-confirmed cases and identified predictors of prolonged fever. Methods: Retrospective study (2021-2026) of 44 patients with confirmed Q fever (mNGS + clinical + exposure criteria). Patients were grouped by post-treatment fever duration (>7 days vs. ≤7 days). Results: Cohort was predominantly middle-aged (median 52.5 years) and male (95.5%). Common presentations: fever (95.5%), headache (45.5%), pulmonary involvement (51.2%). Elevated CRP (97.7%) and ESR (90.9%) were universal. Transient antiphospholipid antibodies (78.9%, all negative at 12 weeks) and ANA (23.5%) were frequent. Prolonged fever (>7 days) was associated with higher WBC, CRP, ESR, lower CD8+ and B cells, and aPL positivity (all p<0.05). Conclusions: Acute Q fever frequently induces transient autoantibodies. Prolonged fever correlates with an inflammatory and lymphopenic phenotype, underscoring immune dysregulation in recovery.
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