Evidence map›Paper›PMID 42488646›Full record

ArticleFrontiers in immunology2026

Clinical and immunological characterization of

Kunihiko Moriya, Yuji Kamiyama, Ryo Ogino, Shuya Kaneko, Takeshi Isoda, Takahiro Kamiya, Yuki Sakai, Fumi Hirose, Hidetoshi Hagiwara, Itaru Iwama and 14 more

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In one paragraph

Article in Frontiers in immunology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

24 authors.

Kunihiko MoriyaDepartment of Pediatrics, National Defense Medical College, Saitama, Japan.
Yuji KamiyamaDepartment of Pediatrics, National Defense Medical College, Saitama, Japan.
Ryo OginoDepartment of Pediatrics, Kyoto University Graduate School of Medicine, Kyoto, Japan.
Shuya KanekoDepartment of Pediatrics and Developmental Biology, Graduate School of Medical and Dental Sciences, Institute of Science Tokyo, Tokyo, Japan.
Takeshi IsodaDepartment of Pediatrics and Developmental Biology, Graduate School of Medical and Dental Sciences, Institute of Science Tokyo, Tokyo, Japan.
Takahiro KamiyaDepartment of Pediatrics and Developmental Biology, Graduate School of Medical and Dental Sciences, Institute of Science Tokyo, Tokyo, Japan.
Yuki SakaiDepartment of Pediatrics, National Defense Medical College, Saitama, Japan.
Fumi HiroseDepartment of Pediatrics, National Defense Medical College, Saitama, Japan.
Hidetoshi HagiwaraDepartment of Pediatrics, National Defense Medical College, Saitama, Japan.
Itaru IwamaDivision of Gastroenterology and Hepatology, Saitama Children's Medical Center, Saitama, Japan.
Ryusuke NambuDivision of Gastroenterology and Hepatology, Saitama Children's Medical Center, Saitama, Japan.
Yoji UejimaDepartment of Infectious Diseases and Immunology, Division of Infectious Diseases and Immunology, Saitama Children's Medical Center, Saitama, Japan.
Fumiaki SakuraDepartment of Pediatrics, Hiroshima University Graduate School of Biomedical and Health Sciences, Hiroshima, Japan.
Miyuki TsumuraDepartment of Pediatrics, Hiroshima University Graduate School of Biomedical and Health Sciences, Hiroshima, Japan.
Kazushi IzawaDepartment of Pediatrics, Kyoto University Graduate School of Medicine, Kyoto, Japan.
Yusuke MatsudaDepartment of Pediatrics, School of Medicine, Institute of Medical, Pharmaceutical and Health Sciences, Kanazawa University, Kanazawa, Japan.
Naoko NakataniDepartment of Pediatrics, Kobe University Graduate School of Medicine, Kobe, Japan.
Akihiro TamuraDepartment of Pediatrics, Kobe University Graduate School of Medicine, Kobe, Japan.
Tomo NozawaDepartment of Pediatrics, Graduate School of Medicine, Yokohama City University, Yokohama, Japan.
Masaki ShimizuDepartment of Pediatrics and Developmental Biology, Graduate School of Medical and Dental Sciences, Institute of Science Tokyo, Tokyo, Japan.
Taizo WadaDepartment of Pediatrics, School of Medicine, Institute of Medical, Pharmaceutical and Health Sciences, Kanazawa University, Kanazawa, Japan.
Satoshi OkadaDepartment of Pediatrics, Hiroshima University Graduate School of Biomedical and Health Sciences, Hiroshima, Japan.
Hirokazu KaneganeDepartment of Child Health and Development, Graduate School of Medical and Dental Sciences, Institute of Science Tokyo, Tokyo, Japan.
Kohsuke ImaiDepartment of Pediatrics, National Defense Medical College, Saitama, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Objective: This study aims to characterize the clinical and immunological profiles of 21 individuals from nine families with this disorder. Methods: Gene panel sequence and/or whole exome sequence, followed by Sanger sequencing, were used to identify and confirm Results: Of the nine Conclusions: In addition to hypogammaglobulinemia/CVID-like phenotype,

Indexed as

AgammaglobulinemiaCommon Variable ImmunodeficiencyHaploinsufficiencyNF-kappa B p50 SubunitAdolescentAdultB-LymphocytesChildChild, PreschoolFemaleHumansImmunophenotypingJapanMaleMiddle AgedPedigreeNF-kappa B p50 SubunitNFKB1 protein, humanautoimmunityautoinfammatory diseasecommon variable immunodeficiency (CVID)inborn errors of immunity (IEI)NFKB1

Identifiers

PMID42488646
PMCPMC13388040

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.