Evidence map›Paper›PMID 42488626›Full record

ArticleFrontiers in immunology2026

Insulin potentiates lipopolysaccharide-induced IL-6 expression through epigenetic remodeling in adipocytes:

Fatemah Bahman, Areej Al-Roub, Nadeem Akther, Ashraf Al Madhoun, Fahd Al-Mulla, Rasheed Ahmad

Abstract read
In one paragraph

Article in Frontiers in immunology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Fatemah BahmanImmunology & Microbiology Department, Dasman Diabetes Institute, Dasman, Kuwait.
Areej Al-Roub *Immunology & Microbiology Department, Dasman Diabetes Institute, Dasman, Kuwait.
Nadeem Akther *Immunology & Microbiology Department, Dasman Diabetes Institute, Dasman, Kuwait.
Ashraf Al MadhounTranslational Research Department, Dasman Diabetes Institute, Dasman, Kuwait.
Fahd Al-MullaTranslational Research Department, Dasman Diabetes Institute, Dasman, Kuwait.
Rasheed AhmadImmunology & Microbiology Department, Dasman Diabetes Institute, Dasman, Kuwait.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Interleukin-6 (IL-6) is a central mediator of chronic low-grade inflammation associated with metabolic disease. Because obesity is characterized by elevated circulating insulin and metabolic endotoxemia, we investigated whether insulin modulates lipopolysaccharide (LPS) induced IL-6 expression in adipocytes and examined the underlying epigenetic mechanisms. Insulin priming markedly enhanced LPS-induced

Indexed as

AdipocytesEpigenesis, GeneticInsulinInterleukin-6Lipopolysaccharides3T3-L1 CellsAcetylationAnimalsHistonesHumansMaleMiceMice, Inbred C57BLPromoter Regions, GeneticSignal TransductionHistonesInsulinInterleukin-6LipopolysaccharidesacetylationadipocytesH3K9IL-6macrophages

Identifiers

PMID42488626
PMCPMC13388075

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.