ArticleFrontiers in physiology2026
Interaction of sublingual glyceryl tri-nitrate administration on single muscle contraction-induced hyperemia: potential insight into the role of the skeletal muscle pump.
Article in Frontiers in physiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Purpose: Much debate exists about the relative contribution of the skeletal muscle pump and rapid vasodilation to exercise hyperemia. This investigation examined the contribution of the skeletal muscle pump to the immediate increase in muscle blood flow (MBF) following a single muscle contraction. Methods: Prior vasodilation using glyceryl tri-nitrate (GTN) abolished the impact of contraction-induced vasodilation following a single contraction. Eight healthy individuals completed a series of three, single muscle contractions at 10% of MVIC, each separated by 90 seconds of recovery for the control (CON) condition. For the GTN condition, participants were given a 0.4 mg dose of GTN sublingually and given enough time for brachial artery diameter to reach a new steady-state. The single contraction model from CON was repeated for GTN condition. Each condition was repeated twice for a total of 6 contractions. Brachial artery diameter and blood velocity were obtained using an ultrasound system operating in Duplex mode. Results: Brachial artery diameter was significantly greater following GTN administration prior to contraction (CON: 0.48 ± 0.07 cm; GTN: 0.56 ± 0.07 cm, p< 0.05, Conclusion: This suggests that the immediate increase in FBF with GTN administration is due to rapid vasodilation and mechanical contraction.
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