Evidence map›Paper›PMID 42488566›Full record

ArticleFrontiers in pharmacology2026

The effect and mechanism of total alkaloids of

Mingxin Pai, Zhongzhi Qi, Xinyu Zhou, Qian Shi, Yexin Wu, Mengru Teng, Yuanyuan Chen, Wai Ming Tse, Kathy Wai Gaun Tse, Mingji Cuomu and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in pharmacology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Mingxin Pai *Nuclear Medicine Department of West China Hospital of Sichuan University, Chengdu, China.
Zhongzhi Qi *Nuclear Medicine Department of West China Hospital of Sichuan University, Chengdu, China.
Xinyu ZhouKey Laboratory of Drug Targeting and Drug Delivery System of the Education Ministry, Sichuan Engineering Laboratory for Plant-Sourced Drug and Sichuan Research Center for Drug Precision Industrial Technology, West China School of Pharmacy Sichuan University, Chengdu, China.
Qian ShiKey Laboratory of Drug Targeting and Drug Delivery System of the Education Ministry, Sichuan Engineering Laboratory for Plant-Sourced Drug and Sichuan Research Center for Drug Precision Industrial Technology, West China School of Pharmacy Sichuan University, Chengdu, China.
Yexin WuKey Laboratory of Drug Targeting and Drug Delivery System of the Education Ministry, Sichuan Engineering Laboratory for Plant-Sourced Drug and Sichuan Research Center for Drug Precision Industrial Technology, West China School of Pharmacy Sichuan University, Chengdu, China.
Mengru TengKey Laboratory of Drug Targeting and Drug Delivery System of the Education Ministry, Sichuan Engineering Laboratory for Plant-Sourced Drug and Sichuan Research Center for Drug Precision Industrial Technology, West China School of Pharmacy Sichuan University, Chengdu, China.
Yuanyuan ChenKey Laboratory of Drug Targeting and Drug Delivery System of the Education Ministry, Sichuan Engineering Laboratory for Plant-Sourced Drug and Sichuan Research Center for Drug Precision Industrial Technology, West China School of Pharmacy Sichuan University, Chengdu, China.
Wai Ming TseNin Jiom Medicine Manufactory (H.K.) Limited, Chengdu, China.
Kathy Wai Gaun TseNin Jiom Medicine Manufactory (H.K.) Limited, Chengdu, China.
Mingji CuomuDepartment of Tibetan Medicine, Xizang University of Tibetan Medicine, Lhasa, China.
Bengui YeKey Laboratory of Drug Targeting and Drug Delivery System of the Education Ministry, Sichuan Engineering Laboratory for Plant-Sourced Drug and Sichuan Research Center for Drug Precision Industrial Technology, West China School of Pharmacy Sichuan University, Chengdu, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Pulmonary fibrosis (PF) is a chronic progressive disease characterized by inflammatory response and fibroblast activation. This process leads to abnormal deposition of extracellular matrix (ECM). However, the existing clinical treatment methods have significant side effects, poor patient compliance, and limited efficacy. Methods: This study examined the efficacy and mechanism of action of the total alkaloids of Results: In BFP-TA, 182 components were detected, comprising 26 alkaloids from genus Conclusion: This study explored the therapeutic effect of BFP-TA on PF. The results showed that BFP-TA may regulate the Rap1/ERK signaling pathway to reduce the expression of pro-inflammatory factors and collagen deposition, thereby improving lung injury and fibrosis. The imperialine in BFP-TA also contributes to the anti-fibrosis ability.

Indexed as

alkaloidsFritillariae Pallidiflorae Bulbusimperialineomicspulmonary fibrosis

Identifiers

PMID42488566
PMCPMC13388258

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.