Evidence map›Paper›PMID 42488556›Full record

ArticleFrontiers in cell and developmental biology2026

TAF7 accumulates in the cytoplasm during cellular transformation and engages STAT3, WASH, and CCT.

Dan Cheng, Elizabeth McManus, Ryan M Young, Thomas Oellerich, Bjorn Haupl, Daniel D Billadeau, Hua Tan, Laura Elnitski, Dinah S Singer

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Article in Frontiers in cell and developmental biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

9 authors.

Dan ChengExperimental Immunology Branch, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, MD, United States.
Elizabeth McManusExperimental Immunology Branch, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, MD, United States.
Ryan M YoungLymphoid Malignancies Branch, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, MD, United States.
Thomas OellerichDepartment of Medicine, Hematology and Oncology, University Hospital, Goethe University Frankfurt, Frankfurt am Main, Frankfurt, Germany.
Bjorn HauplDepartment of Medicine, Hematology and Oncology, University Hospital, Goethe University Frankfurt, Frankfurt am Main, Frankfurt, Germany.
Daniel D BilladeauDivision of Oncology Research, Mayo Clinic College of Medicine, Rochester, MN, United States.
Hua TanTranslational and Functional Genomics Branch, National Human Genome Research Institute, NIH, Bethesda, MD, United States.
Laura ElnitskiTranslational and Functional Genomics Branch, National Human Genome Research Institute, NIH, Bethesda, MD, United States.
Dinah S SingerExperimental Immunology Branch, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, MD, United States.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

TAF7, a core subunit of the general transcription factor TFIID, regulates transcription and additionally functions as an RNA chaperone that directs nascent nuclear RNAs to cytoplasmic polysomes, thereby influencing protein synthesis. Here, we identify a set of novel cytoplasmic interactors and a previously unappreciated cytoplasmic role for TAF7 in oncogenesis. BioID-mediated proximity labeling identified STAT3 and the CCT and WASH complexes as prominent cytoplasmic interactors of TAF7. These interactions were validated by co-immunoprecipitation and proximity ligation assays. We further showed that cytoplasmic TAF7 levels increased during oncogenesis in proportion to cancer cell pathogenicity. Notably, TAF7 engagement with STAT3, CCT and WASH complexes is markedly enhanced during cellular transformation, consistent with their functions in cancer progression. Together, these findings reveal a cytoplasmic TAF7 interactome and implicate elevated cytoplasmic TAF7 as associated with oncogenesis.

Indexed as

CCTcytoplasmic TAF7oncogenesisSTAT3transformationWASH

Identifiers

PMID42488556
PMCPMC13388811

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