ArticleFrontiers in cell and developmental biology2026
Association between acupuncture and IVF outcomes in women with poor ovarian response: a retrospective cohort study.
Article in Frontiers in cell and developmental biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Introduction: Poor ovarian response (POR) is a major barrier to Methods: We conducted a retrospective cohort study of women with POR undergoing IVF at Sichuan Jinxin Xi'nan Women's and Children's Hospital (1 January 2020-31 October 2024). Patients selected acupuncture (typically three sessions per week from ovarian stimulation through the day of embryo transfer) or no acupuncture in either acupuncture group or control group. The primary endpoint was the number of oocytes retrieved. The secondary endpoints included the clinical pregnancy rate (CPR) and live birth rate (LBR). Subgroup analyses were conducted according to the acupuncture dosage (low-dose group: ≤4 sessions, high-dose group: >4 sessions). Results: A total of 2,133 women with POR were included (887 in the acupuncture group and 1,246 in the control group). The baseline demographic and clinical characteristics were comparable between the groups except for follicle-stimulating hormone (FSH) and anti-Müllerian hormone (AMH), and the previous failure cycles, which were adjusted as covariates in multivariable logistic regression. Regarding the primary endpoint, the higher number of retrieved oocytes (median [Q1, Q3]) in the acupuncture group (4.0 [3.0, 7.0] versus 3.0 [1.0, 4.0], Standardized Mean Difference (SMD) = 1.7, 95% confidence interval (CI) [1.53-1.95], Conclusion: In this single-center retrospective cohort, acupuncture was associated with an increased number of retrieved oocytes among women with POR undergoing IVF. Causal inference is limited; randomized trials using standardized acupuncture protocols are warranted.
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