Evidence map›Paper›PMID 42488492›Full record

ArticleSensors and actuators. B, Chemical2026

Magnetic bead electrochemical sandwich assay (MBESA) for the inflammatory cytokine interleukin-1β in fetal membrane on-a-chip studies and placental macrophages.

Hannah A Richards, Olivia E Owens, Jacklyn E Martin, David E Cliffel

Abstract read
In one paragraph

Article in Sensors and actuators. B, Chemical, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Hannah A RichardsDepartment of Chemistry, Vanderbilt University, 1234 Stevenson Center Lane, Nashville, TN 37240, USA.
Olivia E OwensDepartment of Chemistry, Vanderbilt University, 1234 Stevenson Center Lane, Nashville, TN 37240, USA.ORCID 0000-0003-2061-1530
Jacklyn E MartinDepartment of Chemistry, Lebanon Valley College, 101 N. College Ave, Annville, PA 17003, USA.ORCID 0009-0008-4044-3013
David E CliffelDepartment of Chemistry, Vanderbilt University, 1234 Stevenson Center Lane, Nashville, TN 37240, USA.ORCID 0000-0001-8756-106X

Funding

TRAINING PROGRAM IN ENVIRONMENTAL TOXICOLOGYT32ES007028 · NIEHS · VANDERBILT UNIVERSITY · PI F PETER Guengerich, Fiona Edith Harrison · 1985 to 2026
$15.7M
Instrumenting the Fetal Membrane on a ChipR01HD102752 · NICHD · VANDERBILT UNIVERSITY · PI CLIFFEL, DAVID E · 2020 to 2023
$2.5M
NICHD NIH HHS R01 HD102752NIEHS NIH HHS T32 ES007028
6 · The paper itself

Abstract

Preterm birth (PTB), triggered by preterm premature rupture of membranes (PPROM), remains a global health challenge, often linked to infections like chorioamnionitis. Existing biomarker detection methods, such as ELI-SAs, are limited by time, cost, and reagent requirements. There is a significant demand for new analytical techniques that identify PTB biomarkers, such as the inflammatory cytokine interleukin-1β (IL-1β), within biological models. In this work, we have quantified IL-1β with our newly developed magnetic bead electrochemical sandwich assay (MBESA), an alternative to traditional ELISAs. We have utilized a fetal membrane organ on-a-chip (FMOC) to mimic the physiological functions of the human fetal membranes during bacterial infections

Indexed as

BiosensorsElectrochemical sensorFetal membrane on chipImmunoassaysMagnetic BeadsMicrofluidicsOrgan on chip

Identifiers

PMID42488492
PMCPMC13390796

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.