Evidence map›Paper›PMID 42488471›Full record

ArticleHemaSphere2026

Preclinical evaluation of the ROR1-targeting antibody-drug conjugates zilovertamab vedotin and VLS-211 against B-cell ALL patient-derived xenografts.

Christopher M Smith, Ben Watts, Kathryn Evans, Hansen Kosasih, Chelsea Mayoh, Stephen W Erickson, Eric J Earley, Steven Neuhauser, Timothy M Stearns, Vivek M Philip and 9 more

Abstract read
In one paragraph

Article in HemaSphere, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors.

Christopher M SmithChildren's Cancer Institute, Lowy Cancer Research Centre, School of Clinical Medicine, UNSW Medicine & Health UNSW Centre for Childhood Cancer Research, UNSW Sydney Sydney New South Wales Australia.
Ben WattsChildren's Cancer Institute, Lowy Cancer Research Centre, School of Clinical Medicine, UNSW Medicine & Health UNSW Centre for Childhood Cancer Research, UNSW Sydney Sydney New South Wales Australia.
Kathryn EvansChildren's Cancer Institute, Lowy Cancer Research Centre, School of Clinical Medicine, UNSW Medicine & Health UNSW Centre for Childhood Cancer Research, UNSW Sydney Sydney New South Wales Australia.
Hansen KosasihChildren's Cancer Institute, Lowy Cancer Research Centre, School of Clinical Medicine, UNSW Medicine & Health UNSW Centre for Childhood Cancer Research, UNSW Sydney Sydney New South Wales Australia.ORCID https://orcid.org/0000-0002-0428-6195
Chelsea MayohChildren's Cancer Institute, Lowy Cancer Research Centre, School of Clinical Medicine, UNSW Medicine & Health UNSW Centre for Childhood Cancer Research, UNSW Sydney Sydney New South Wales Australia.
Stephen W EricksonRTI International, Research Triangle Park North Carolina USA.
Eric J EarleyRTI International, Research Triangle Park North Carolina USA.
Steven NeuhauserThe Jackson Laboratory for Mammalian Genetics Bar Harbor Maine USA.
Timothy M StearnsThe Jackson Laboratory for Mammalian Genetics Bar Harbor Maine USA.
Vivek M PhilipThe Jackson Laboratory for Mammalian Genetics Bar Harbor Maine USA.
Jeffrey H ChuangThe Jackson Laboratory for Genomic Medicine Farmington Connecticut USA.
Charles E de BockChildren's Cancer Institute, Lowy Cancer Research Centre, School of Clinical Medicine, UNSW Medicine & Health UNSW Centre for Childhood Cancer Research, UNSW Sydney Sydney New South Wales Australia.ORCID https://orcid.org/0000-0001-5182-8535
Edward P BowmanDepartment of Oncology Merck & Co. Inc. Rahway New Jersey USA.
Katti A JessenFormerly VelosBio Inc. San Diego California USA.
Emily L JocoyThe Jackson Laboratory Sacramento California USA.
Carol J BultThe Jackson Laboratory for Mammalian Genetics Bar Harbor Maine USA.
Beverly A TeicherNational Cancer Institute Bethesda Maryland USA.
Malcolm A SmithNational Cancer Institute Bethesda Maryland USA.
Richard B LockChildren's Cancer Institute, Lowy Cancer Research Centre, School of Clinical Medicine, UNSW Medicine & Health UNSW Centre for Childhood Cancer Research, UNSW Sydney Sydney New South Wales Australia.ORCID https://orcid.org/0000-0002-3436-9071

Funding

Pediatric Preclinical Testing Consortium - LeukemiaU01CA199000 · NCI · UNIVERSITY OF NEW SOUTH WALES · PI Richard B Lock · 2015 to 2026
$4.8M
Pediatric Oncology In Vivo Testing Program Coordinating CenterU24CA263963 · NCI · JACKSON LABORATORY · PI CAROL J BULT, Jeffrey Hsu-Min Chuang · 2021 to 2026
$4.7M
Pediatric Preclinical Testing Consortium: Coordinating Center-Additional PPTC funding extensionU01CA199222 · NCI · RESEARCH TRIANGLE INSTITUTE · PI GATTO, GREGORY J · 2015 to 2021
$2.6M
NCI NIH HHS U01 CA199000NCI NIH HHS U01 CA199222NCI NIH HHS U24 CA263963
6 · The paper itself

Abstract

Although survival rates for acute lymphoblastic leukemia (ALL) have improved dramatically over the past 60 years, outcomes vary across different molecular subtypes and risk categories, and a significant number of patients remain difficult to treat. ROR1 is a receptor tyrosine kinase expressed in B-cell ALL, particularly in patients with

Identifiers

PMID42488471
PMCPMC13390736

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.