Evidence map›Paper›PMID 42488462›Full record

ArticleChemical science2026

Cucurbit[6]uril-monoazide: towards functional CB[6]-tethered DNA (pseudo)rotaxanes.

Noah Beltrami, Soumen Pradhan, Nathan A Rudman, Aunindya Jyoti, Olaide Adekusibe, E Berk Atuk, Mohammed Amin Zarandi, Moamen Ismail, Avery G Franques, Husain N Kagalwala and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Chemical science, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Noah BeltramiDepartment of Chemistry, Tulane University 2015 Percival Stern Hall New Orleans Louisiana 70118 USA.
Soumen PradhanDepartment of Chemistry, Southern Methodist University 3215 Daniel Ave, Fondren Science Bldg Dallas Texas 75275 USA jananj@smu.edu.ORCID https://orcid.org/0000-0002-0858-0068
Nathan A RudmanDepartment of Chemistry, University of Pennsylvania 231 South 34th Street Philadelphia PA 19104-6323 USA.ORCID https://orcid.org/0000-0002-9938-3544
Aunindya JyotiDepartment of Chemistry, Southern Methodist University 3215 Daniel Ave, Fondren Science Bldg Dallas Texas 75275 USA jananj@smu.edu.ORCID https://orcid.org/0009-0004-5879-4592
Olaide AdekusibeDepartment of Chemistry, Tulane University 2015 Percival Stern Hall New Orleans Louisiana 70118 USA.ORCID https://orcid.org/0009-0005-5270-3765
E Berk AtukDepartment of Chemistry, Tulane University 2015 Percival Stern Hall New Orleans Louisiana 70118 USA.
Mohammed Amin ZarandiDepartment of Chemistry, Tulane University 2015 Percival Stern Hall New Orleans Louisiana 70118 USA.
Moamen IsmailDepartment of Chemistry, Tulane University 2015 Percival Stern Hall New Orleans Louisiana 70118 USA.ORCID https://orcid.org/0009-0002-1068-9676
Avery G FranquesDepartment of Chemistry, Tulane University 2015 Percival Stern Hall New Orleans Louisiana 70118 USA.
Husain N KagalwalaDepartment of Chemistry, Southern Methodist University 3215 Daniel Ave, Fondren Science Bldg Dallas Texas 75275 USA jananj@smu.edu.ORCID https://orcid.org/0000-0002-5628-5901
Ivan J DmochowskiDepartment of Chemistry, University of Pennsylvania 231 South 34th Street Philadelphia PA 19104-6323 USA.ORCID https://orcid.org/0000-0001-7162-1347
Janarthanan JayawickramarajahDepartment of Chemistry, Southern Methodist University 3215 Daniel Ave, Fondren Science Bldg Dallas Texas 75275 USA jananj@smu.edu.ORCID https://orcid.org/0000-0001-5271-1523

Funding

Designer Molecular Probes for Biomedical ApplicationsR35GM131907 · NIGMS · UNIVERSITY OF PENNSYLVANIA · PI Ivan Julian Dmochowski · 2019 to 2026
$4.7M
NIGMS NIH HHS R35 GM131907
6 · The paper itself

Abstract

Cucurbit[6]uril, CB[6], is an important host due to its aqueous molecular recognition and metal-free click chemistry properties. A crucial missing link in the field is the installation of appropriate functionalizable handles on these hosts, which could then be covalently coupled to biomacromolecules. This, in turn, would help realize the full potential of CB[6]-based systems, especially in biomedical and bioimaging applications. However, there has been no development of CB[6] derivatives that can undergo such direct one-to-one conjugations. Here, we demonstrate the first synthesis of a CB[6]-monoazide (CB[6]-N

Identifiers

PMID42488462
PMCPMC13390680

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.