Evidence map›Paper›PMID 42488427›Full record

ReviewFrontiers in cellular and infection microbiology2026

Periodontitis and MASLD: a narrative review of the direct oral-hepatic pathway.

Hai He, Zishuai Chen, Hengxiang Liu, Xiaohua Zhang, Zhiqiang Li, Tianzhu Song, Zifan Wang

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Frontiers in cellular and infection microbiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Hai HeKey Laboratory of Biotechnology and Bioengineering of State Ethnic Affairs Commission, Biomedical Research Center, School of Bioengineering Northwest Minzu University, Lanzhou, Gansu, China.
Zishuai ChenKey Laboratory of Biotechnology and Bioengineering of State Ethnic Affairs Commission, Biomedical Research Center, School of Bioengineering Northwest Minzu University, Lanzhou, Gansu, China.
Hengxiang LiuKey Laboratory of Biotechnology and Bioengineering of State Ethnic Affairs Commission, Biomedical Research Center, School of Bioengineering Northwest Minzu University, Lanzhou, Gansu, China.
Xiaohua ZhangSchool of Stomatology, Key Laboratory of Oral Diseases of Gansu Province, Key Laboratory of Stomatology of State Ethnic Afairs Commission, Northwest Minzu University, Lanzhou, Gansu, China.
Zhiqiang LiSchool of Stomatology, Key Laboratory of Oral Diseases of Gansu Province, Key Laboratory of Stomatology of State Ethnic Afairs Commission, Northwest Minzu University, Lanzhou, Gansu, China.
Tianzhu SongSchool of Stomatology, Key Laboratory of Oral Diseases of Gansu Province, Key Laboratory of Stomatology of State Ethnic Afairs Commission, Northwest Minzu University, Lanzhou, Gansu, China.
Zifan WangKey Laboratory of Biotechnology and Bioengineering of State Ethnic Affairs Commission, Biomedical Research Center, School of Bioengineering Northwest Minzu University, Lanzhou, Gansu, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Metabolic dysfunction-associated steatotic liver disease (MASLD) affects over 30% of adults globally, yet no pharmacotherapies are approved for its early stages. Emerging evidence from preclinical models and limited observational studies suggests that periodontitis may represent a biologically plausible, modifiable risk factor for MASLD through proposed direct oral--hepatic pathways; however, causal relationships remain to be established, and these pathways are currently insufficiently validated in humans. This narrative review synthesizes evidence ranging predominantly from

Indexed as

Fatty LiverLiverPeriodontitisAnimalsHumansInflammasomesReactive Oxygen SpeciesSignal TransductionInflammasomesReactive Oxygen Speciesdirect oral hepatic pathwayhepatic steatosisliver fibrosisMASLDperiodontitis

Identifiers

PMID42488427
PMCPMC13388143

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.