Evidence map›Paper›PMID 42488420›Full record

ArticleFrontiers in cellular and infection microbiology2026

Clinical characteristics and epidemiological analysis of 23 cases of tick-borne rickettsiosis in Xinjiang Uygur Autonomous Region.

Minghui Yun, Ziqi Wang, Xiaoshuang Han, Xiangwei Wu, Chao Wei, Kaiting Zhang, Yang Zhou, Xiaobo Lu, Yuanzhi Wang, Ligu Mi and 1 more

Abstract read
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In one paragraph

Article in Frontiers in cellular and infection microbiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Minghui Yun *NHC Key Laboratory of Prevention and Treatment of Central Asia High Incidence Diseases, the First Affiliated Hospital of Shihezi University, Shihezi, China.
Ziqi Wang *Key Laboratory for Prevention and Control of Emerging Infectious Diseases and Public Health Security of the XPCC, School of Medicine, Shihezi University, Shihezi, China.
Xiaoshuang Han *Infectious Disease and Liver Disease Center, The First Affiliated Hospital of Xinjiang Medical University, Urumqi, Xinjiang, China.
Xiangwei Wu *NHC Key Laboratory of Prevention and Treatment of Central Asia High Incidence Diseases, the First Affiliated Hospital of Shihezi University, Shihezi, China.
Chao WeiNHC Key Laboratory of Prevention and Treatment of Central Asia High Incidence Diseases, the First Affiliated Hospital of Shihezi University, Shihezi, China.
Kaiting ZhangNHC Key Laboratory of Prevention and Treatment of Central Asia High Incidence Diseases, the First Affiliated Hospital of Shihezi University, Shihezi, China.
Yang ZhouNHC Key Laboratory of Prevention and Treatment of Central Asia High Incidence Diseases, the First Affiliated Hospital of Shihezi University, Shihezi, China.
Xiaobo LuInfectious Disease and Liver Disease Center, The First Affiliated Hospital of Xinjiang Medical University, Urumqi, Xinjiang, China.
Yuanzhi WangNHC Key Laboratory of Prevention and Treatment of Central Asia High Incidence Diseases, the First Affiliated Hospital of Shihezi University, Shihezi, China.
Ligu MiKey Laboratory for Prevention and Control of Emerging Infectious Diseases and Public Health Security of the XPCC, School of Medicine, Shihezi University, Shihezi, China.
Songsong XieNHC Key Laboratory of Prevention and Treatment of Central Asia High Incidence Diseases, the First Affiliated Hospital of Shihezi University, Shihezi, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Previously, at least ten spotted fever group Methods: During April 2017 - May 2025, the blood samples of 70 tick-bitten patients in XUAR were collected. Their blood DNAs were individually extracted, and rickettsia-specific gene fragments were further detected by nested polymerase chain reaction (nPCR). Meanwhile, combined with sequencing of 16S rRNA V3/V4 region in blood pools and serological examination, clinical symptoms, laboratory test results and antibiotic treatment were further analyzed. Results: Out of 70 tick-bitten cases, 23 patients were confirmed to be infected with SFGR, including Conclusion: In this study of 70 tick-bitten patients who visited the First Affiliated Hospital of Shihezi University from April 2017 to May 2025, the SFGR infection rate was 32.9% (23/70). Early diagnosis and timely treatment are crucial in spotted fever cases. Early administration of doxycycline is effective against SFGR infection, and delayed treatment increases the risk of severe outcomes. The methods of nucleic acid diagnosis, such as nPCR and next-generation sequencing (NGS), should be implemented especially in acute tick-bitten patients.

Indexed as

RickettsiaRickettsia InfectionsTick-Borne DiseasesAdultAgedAnimalsAnti-Bacterial AgentsChinaDNA, BacterialDoxycyclineFemaleHumansMaleMiddle AgedPolymerase Chain ReactionRNA, Ribosomal, 16SAnti-Bacterial AgentsDNA, BacterialDoxycyclineRNA, Ribosomal, 16Sclinical symptomsdoxycycline treatmentlaboratory testsmisdiagnosismolecular detectionspotted fever group rickettsia

Identifiers

PMID42488420
PMCPMC13388217

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.