ArticleFrontiers in cellular and infection microbiology2026
Tumor tissue-associated
Article in Frontiers in cellular and infection microbiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
13 authors.
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Abstract
Background: Lymph node metastasis (LNM) critically influences prognosis in colorectal cancer (CRC), yet the mechanisms driving this process, particularly the contribution of the intratumoral microbiota, remain insufficiently defined. Methods: We performed 16S rRNA sequencing on tumor tissue from a discovery cohort of 122 CRC patients, followed by validation in one internal and one external validation cohort. Immunohistochemistry (IHC), fluorescence Results: Higher tumor tissue-associated Phascolarctobacterium abundance showed a modest positive association with lymph node metastasis and was associated with worse overall survival in the discovery cohort (HR = 3.892, 95% CI = 1.441-10.513, P = 0.007). These tumors showed exploratory immune-contexture differences, including lower CD8+ T-cell-related signals and higher macrophage/M2 macrophage-related signals. WGCNA identified exploratory abundance-associated modules enriched in keratinocyte differentiation, epithelial development, and MAPK signaling, whereas low-abundance-associated modules were linked to lipid metabolism and redox regulation. Conclusions: Tumor tissue-associated
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