t-PA/PAI-1 complex expression correlates with the severity in hantaan virus-induced hemorrhagic fever with renal syndrome.

Objectives: This study aimed to investigate t-PAIC concentration changes across severity levels in HFRS patients and evaluate its value in predicting disease severity, providing a potential biomarker for HFRS severity assessment and monitoring. Methods: t-PAIC levels were measured by chemiluminescence immunoassay in 156 HFRS patients and 37 healthy controls. Routine laboratory tests assessed WBC, PLT, Cr, UA, urea, HDL, ALB, APTT, and PT. HFRS-specific antibodies were detected using the colloidal gold method. Spearman correlation analysis evaluated associations between t-PAIC and clinical indices. Ordinal logistic regression identified risk factors linked to disease severity. ROC curve analysis assessed the predictive performance of t-PAIC for HFRS severity. Results: t-PAIC levels progressively increased with HFRS severity, peaking in critically ill patients. t-PAIC showed significant positive correlations with leukocyte count ( Conclusions: t-PAIC levels closely reflect HFRS severity and associated clinical features, including renal dysfunction and coagulation abnormalities, suggesting its potential as a biomarker for monitoring disease status.