Evidence map›Paper›PMID 42488356›Full record

ArticleImaging neuroscience (Cambridge, Mass.)

Five-year associations among dopamine D2-like receptor loss, cognitive decline, education, and self-reported leisure activities in healthy older adults.

Amos Pagin, Nina Karalija, Micael Andersson, Lars Nyberg, Lars Bäckman, Katrine Riklund, Ulman Lindenberger, Martin Lövdén

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Imaging neuroscience (Cambridge, Mass.). The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Amos PaginDepartment of Psychology, University of Gothenburg, Gothenburg, Sweden.ORCID https://orcid.org/0000-0002-1124-8277
Nina KaralijaUmeå Center for Functional Brain Imaging, Umeå University, Umeå, Sweden.
Micael AnderssonUmeå Center for Functional Brain Imaging, Umeå University, Umeå, Sweden.
Lars NybergUmeå Center for Functional Brain Imaging, Umeå University, Umeå, Sweden.
Lars BäckmanAging Research Center, Karolinska Institute and Stockholm University, Solna, Sweden.
Katrine RiklundUmeå Center for Functional Brain Imaging, Umeå University, Umeå, Sweden.
Ulman LindenbergerCenter for Lifespan Psychology, Max Planck Institute for Human Development, Berlin, Germany.
Martin LövdénDepartment of Psychology, University of Gothenburg, Gothenburg, Sweden.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Age-related loss of dopamine (DA) integrity has been linked to cognitive decline. Relatedly, education and leisure activity engagement have been highlighted as neurocognitive protective factors, but their associations with DA integrity remain poorly understood. Using Bayesian structural equation modeling, we analyzed longitudinal data from the Cognition, Brain, and Aging (COBRA) prospective cohort study with 181 older adults at baseline to examine correlations among DA D2-like receptor (DRD2) availability in the caudate and putamen, measured using [

Indexed as

agingcognitioncognitive reservedopamineeducationleisure activities

Identifiers

PMID42488356
PMCPMC13389743

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.