Evidence map›Paper›PMID 42488207›Full record

ArticleFrontiers in nutrition2026

Comparative structural characterization and protective effects against myocardial ischemia/reperfusion injury of polysaccharides from two major Chinese yam cultivars (

Guojie Xie, Longqin Li, Xueqian Hu, Ang Ma, Yi Ying, Shujie Zhang, Hai-Ning Lyu, Hui Zhao, Xiaoyu Hu, Zipeng Gong and 2 more

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Article in Frontiers in nutrition, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

12 authors.

Guojie Xie *Guizhou Provincial Key Laboratory of Pathogenesis and Drug Research on Common Chronic Diseases, School of Basic Medical Sciences and School of Pharmaceutical Sciences, Guizhou Medical University, Guiyang, China.
Longqin Li *Guizhou Provincial Key Laboratory of Pathogenesis and Drug Research on Common Chronic Diseases, School of Basic Medical Sciences and School of Pharmaceutical Sciences, Guizhou Medical University, Guiyang, China.
Xueqian Hu *Department of Oncology, Ningbo Municipal Hospital of Traditional Chinese Medicine Affiliated to Zhejiang Chinese Medical University, Ningbo, China.
Ang MaState Key Laboratory for Quality Assurance and Sustainable Use of Dao-di Herbs, Artemisinin Research Center, Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing, China.
Yi YingState Key Laboratory for Quality Assurance and Sustainable Use of Dao-di Herbs, Artemisinin Research Center, Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing, China.
Shujie ZhangState Key Laboratory for Quality Assurance and Sustainable Use of Dao-di Herbs, Artemisinin Research Center, Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing, China.
Hai-Ning LyuState Key Laboratory for Quality Assurance and Sustainable Use of Dao-di Herbs, Artemisinin Research Center, Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing, China.
Hui ZhaoSchool of Traditional Chinese Medicine, Southern Medical University, Guangzhou, China.
Xiaoyu HuState Key Laboratory for Quality Assurance and Sustainable Use of Dao-di Herbs, Artemisinin Research Center, Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing, China.
Zipeng GongGuizhou Provincial Key Laboratory of Pathogenesis and Drug Research on Common Chronic Diseases, School of Basic Medical Sciences and School of Pharmaceutical Sciences, Guizhou Medical University, Guiyang, China.
Jigang WangGuizhou Provincial Key Laboratory of Pathogenesis and Drug Research on Common Chronic Diseases, School of Basic Medical Sciences and School of Pharmaceutical Sciences, Guizhou Medical University, Guiyang, China.
Dandan LiuState Key Laboratory for Quality Assurance and Sustainable Use of Dao-di Herbs, Artemisinin Research Center, Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Chinese yam ( Methods: The molecular weight distribution, monosaccharide composition, UV-visible spectra, and FT-IR characteristics of the two polysaccharide fractions were compared. Their protective effects were evaluated in H9c2 cells subjected to oxygen-glucose deprivation/reoxygenation (OGD/R) and in a rat model of myocardial ischemia/reperfusion injury (MI/RI). Furthermore, transcriptomics, proteomics, and Western blotting were integrated to investigate the underlying mechanisms. Results: CYP-XBZ and CYP-TG exhibited broadly similar molecular weight distribution patterns, glucan-dominant monosaccharide compositions, and characteristic polysaccharide spectral features. However, minor differences in molecular heterogeneity and monosaccharide proportions were observed. In OGD/R-treated H9c2 cells, both fractions significantly improved cell viability and reduced CK-MB, cTnT, and 8-OHdG levels. Multi-omics analyses revealed that the shared protective effects were mainly associated with stress and inflammation-related pathways, particularly the MyD88-associated MAPK and NF-κB signaling pathways. These findings were further confirmed by Western blotting. In the rat model of MI/RI, oral administration of both polysaccharide fractions reduced infarct size and alleviated histopathological injury. They also decreased serum biomarkers of myocardial injury and oxidative stress. Conclusion: Polysaccharides from the two major Chinese yam cultivars showed highly comparable structural features, cardio protective effects, and regulatory mechanisms. These findings support the functional consistency of these cultivars as sources of bioactive polysaccharides and highlight their potential as food-derived functional ingredients for cardiovascular and nutrition-related health.

Indexed as

Chinese yamcultivar comparisonfunctional ingredientmyocardial ischemia/reperfusion injurypolysaccharidesstructural characterization

Identifiers

PMID42488207
PMCPMC13389841

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