Evidence map›Paper›PMID 42488171›Full record

ArticleJAMIA open2026

From clinics to discoveries: harnessing national EHR interoperability for research.

Josh Lemieux, Emily R Pfaff, Richard A Moffitt, Jay Nakashima, Raymond Duncan, Erica Galvez, John P Giannini, Julie A McMurry, Anita Walden, Melissa Haendel

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in JAMIA open, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Josh LemieuxDepartment of Genetics, University of North Carolina, Chapel Hill, NC 27599, United States.
Emily R PfaffDepartment of Medicine, University of North Carolina, Chapel Hill, NC 27599, United States.ORCID https://orcid.org/0000-0002-6840-9756
Richard A MoffittDepartment of Hematology and Medical Oncology, Department of Biomedical Informatics, Emory University, Atlanta, GA 30032, United States.
Jay NakashimaeHealth Exchange, Denver, CO 80210, United States.
Raymond DuncanEnterprise Information Services, Cedars-Sinai Medical Center, Los Angeles, CA 90066, United States.
Erica GalvezManifest MedEx, Riverside, CA 92506, United States.
John P GianniniAll of Us Research Program, National Institutes of Health, Bethesda, MD 20817, United States.
Julie A McMurryDepartment of Genetics, University of North Carolina, Chapel Hill, NC 27599, United States.
Anita WaldenDepartment of Genetics, University of North Carolina, Chapel Hill, NC 27599, United States.
Melissa HaendelDepartment of Genetics, University of North Carolina, Chapel Hill, NC 27599, United States.ORCID https://orcid.org/0000-0001-9114-8737

Funding

Iron-CLAD: securely advancing AoU participant characterization with provenplatforms and collaborationsOT2OD036113 · OD · UNIV OF NORTH CAROLINA CHAPEL HILL · PI CHRISTOPHER G CHUTE, MELISSA A HAENDEL · 2023 to 2026
$49.1M
NIH HHS OT2 OD036113
6 · The paper itself

Abstract

Objectives: To assess whether existing nationwide Health Information Networks (HINs) and Health Information Exchanges (HIEs) can be leveraged for electronic health record (EHR) data acquisition for research-specifically, for the NIH's Materials and Methods: The Results: Newly obtained records provided complementary information, enhancing completeness and research utility. Discussion: This pilot demonstrates the feasibility of using HINs/HIEs for patient-authorized data exchange for research. Barriers remain-including inconsistent technical capacity to transact authorizations and data quality variations. Conclusion: HINs and HIEs can support secure, patient-authorized EHR exchange for research, offering a pathway to more comprehensive, participant-driven biomedical discovery.

Indexed as

EHR datahealth information exchangeinteroperabilityreal-world data

Identifiers

PMID42488171
PMCPMC13390099

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.