Evidence map›Paper›PMID 42488154›Full record

ArticleHeart rhythm O22026

Real-world data of sex differences in atrial fibrillation catheter ablation: Insights from a prospective multicenter registry.

Zhuxin Zhang, Daniela Hincapie, Christopher Thorne, Allyson Varley, Linda Justice, Jose Osorio, Anthony Moretta, Joshua Silverstein, Anil Rajendra, Gustavo Morales and 15 more

Registry-linked trialAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Heart rhythm O2, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04088071 (Real-world Experience of Catheter Ablation for the Treatment of Arrhythmias Symptomatic Using Novel CARTO Technologies), which is not on this map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04088071 recruitingnot on this map

Real-world Experience of Catheter Ablation for the Treatment of Arrhythmias Symptomatic Using Novel CARTO Technologies: REAL Registry

Typeobservational_patient_registrySponsorHeart Rhythm Clinical and Research Solutions, LLCRan2018 to 2028Enrolled20,000ConditionsParoxysmal Atrial Fibrillation, Persistent Atrial Fibrillation, Ventricular ArrhythmiaArmsCatheter ablation
3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

25 authors.

Zhuxin ZhangCardiac Arrhythmia Service, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts.
Daniela HincapieCardiac Arrhythmia Service, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts.
Christopher ThorneHeart Rhythm Clinical and Research Solutions, Birmingham, Alabama.
Allyson VarleyHeart Rhythm Clinical and Research Solutions, Birmingham, Alabama.
Linda JusticeHeart Rhythm Clinical and Research Solutions, Birmingham, Alabama.
Jose OsorioCardiac Arrhythmia Service, HCA Florida, Miami, Florida.
Anthony MorettaCardiac Arrhythmia Service, Sarasota Memorial Hospital, Sarasota, Florida.
Joshua SilversteinCardiac Arrhythmia Service, Allegheny Health Network, Pittsburgh, Pennsylvania.
Anil RajendraCardiac Arrhythmia Service, Arrhythmia Institute at Grandview, Birmingham, Alabama.
Gustavo MoralesCardiac Arrhythmia Service, Arrhythmia Institute at Grandview, Birmingham, Alabama.
Sandeep GoyalCardiac Arrhythmia Service, Piedmont Hospital, Atlanta, Georgia.
Yaariv KhaykinCardiac Arrhythmia Service, Southlake Regional Health Centre, Ontario, Canada.
Mouhannad SadekCardiac Arrhythmia Service, Southlake Regional Health Centre, Ontario, Canada.
Benjamin D'SouzaPerelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania.
Imdad AhmedCardiac Arrhythmia Service, MercyHealth, Janesville, Wisconsin.
Mohammad Ali JazayeriCardiac Arrhythmia Service, Trinity Health Michigan Heart-Ann Arbor Campus, Ypsilanti, Michigan.
Subha VarahanCardiac Arrhythmia Service, Oklahoma Heart Hospital, Oklahoma City, Oklahoma.
Matthew SackettCardiac Arrhythmia Service, Centra Heart and Vascular Institute, Lynchburg, Virginia.
Julia McHughCardiac Arrhythmia Service, Centra Heart and Vascular Institute, Lynchburg, Virginia.
Alexandru CosteaCardiac Arrhythmia Service, The Christ Hospital Health Network, Cincinnati, Ohio.
Ann Lowery BlackCardiac Arrhythmia Service, HCA Florida, Miami, Florida.
Yan YaoArrhythmia Center, State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
William H SauerCardiac Arrhythmia Service, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts.
Paul C ZeiCardiac Arrhythmia Service, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts.
REAL-AF Investigators

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Sex differences in atrial fibrillation (AF) ablation strategies and outcomes remain insufficiently characterized. Objective: This study aimed to evaluate the impact of sex on ablation strategies and clinical outcomes in patients with paroxysmal (PAF) and persistent AF (PsAF) in real-world settings. Methods: Data from the REAL-AF registry were analyzed (January 2018 to May 2023). Demographics, intraoperative parameters, and outcomes were compared by sex, stratified by AF type. Results: A total of 4202 patients (41.1% women) were included. Women were older (69.02 ± 9.18 vs 65.32 ± 10.49 years), had higher CHA Conclusion: Women face higher long-term arrhythmia recurrence risks, especially in ablation strategies involving SM, despite comparable acute and short-term outcomes. Clinical trial registration: NCT04088071.

Indexed as

Ablation strategyAtrial fibrillationCatheter ablationQuality improvementWomen’s health

Identifiers

PMID42488154
PMCPMC13390002

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.