ArticleHeart rhythm O22026
Rotor-guided tailor-made pulmonary vein isolation for persistent atrial fibrillation: Identification of the left atrial septum as a common arrhythmogenic substrate.
Article in Heart rhythm O2, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: In patients with persistent atrial fibrillation (AF), additional substrate modification beyond pulmonary vein isolation (PVI) is controversial, given limited durability and increased atrial tachycardias (ATs). ExTRa Mapping system is a new tool to clarify the real-time imaging of AF rotors. Objective: We evaluated the efficacy of extended PVI that combines cryoballoon PVI with tailor-made radiofrequency (RF) ablation of pulmonary vein antrum rotors identified by ExTRa Mapping. Methods: 58 patients with persistent AF underwent initial ablation using a tailored strategy: cryoballoon PVI followed by RF line extension to encompass adjacent AF rotors identified by ExTRa Mapping (rotor-guided extended PVI group). Outcomes were compared with 2 contemporaneous control groups: (1) cryoballoon PVI alone (PVI-alone group, n = 33) and (2) RF-based PVI plus posterior wall isolation (PWI) (PVI + PWI group, n = 43). The primary endpoint was freedom from AF/AT recurrence without antiarrhythmic drugs at 12 months. Results: Baseline characteristics were comparable among groups. Left atrial septal Nonpassively activated areas were observed in 70.7% of patients and were the most common location. Accordingly, in the rotor-guided extended PVI group, anterior extension from the right pulmonary vein toward the left atrial septal rotor was the most frequently applied strategy. At 12 months, freedom from AF/AT was significantly higher in the rotor-guided extended PVI group (89.7%) than the PVI-alone group (63.6%) and the PVI + PWI group (65.1%) (log-rank Conclusion: Cryoballoon PVI combined with ExTRa Mapping-guided RF ablation targeting adjacent rotors improves arrhythmia outcomes without increasing ATs.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.