Evidence map›Paper›PMID 42488125›Full record

ArticleFrontiers in oncology2026

Implementing exercise interventions in pediatric oncology: an expert consensus framework from the FORTEe project.

Marie A Neu, Elias Dreismickenbecker, Lena Wypyrsczyk, Filippo Spreafico, Adriana Balduzzi, Barbara Heißerer, Hayley Marriott, Norbert W Paul, Eila Watson, Wilhelm Bloch and 25 more

Registry-linked trialAbstract read
In one paragraph

Article in Frontiers in oncology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05289739 (Get Strong to Fight Childhood Cancer), which is not on this map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05289739 nacompletednot on this map

Get Strong to Fight Childhood Cancer: An Exercise Intervention for Children and Adolescents Undergoing Anti-Cancer Treatment

TypeinterventionalSponsorJohannes Gutenberg University MainzRan2022 to 2026Enrolled478ConditionsPediatric OncologyArmsExercise training
3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

35 authors.

Marie A NeuUniversity Medical Center of the Johannes Gutenberg-University Mainz, Childhood Cancer Center Mainz, Mainz, Germany.
Elias DreismickenbeckerUniversity Medical Center of the Johannes Gutenberg-University Mainz, Childhood Cancer Center Mainz, Mainz, Germany.
Lena WypyrsczykUniversity Medical Center of the Johannes Gutenberg-University Mainz, Childhood Cancer Center Mainz, Mainz, Germany.
Filippo SpreaficoOncology Unit, IRCCS Istituto Giannina Gaslini, Genoa, Italy.
Adriana BalduzziFondazione Monza e Brianza per Il Bambino e La Sua Mamma, Centro Maria Letizia Verga, Monza, Italy.
Barbara HeißererConcentris research management gmbh, Fürstenfeldbruck, Germany.
Hayley MarriottOxford Brookes University, School of Sport, Nutrition and Allied Health Professions, Oxford, United Kingdom.
Norbert W PaulUniversity Medical Center of the Johannes Gutenberg-University Mainz, Institute for the History, Philosophy and Ethics of Medicine, Mainz, Germany.
Eila WatsonOxford Brookes University, Institute of Applied Health Research, Oxford, United Kingdom.
Wilhelm BlochGerman Sport University Cologne, Department of Molecular and Cellular Sport Medicine at the Institute of Cardiovascular Research and Sports Medicine, Cologne, Germany.
Martin Kaj FridhUniversity Hospital Copenhagen, Rigshospitalet, Department of Pediatrics and Adolescent Medicine, Copenhagen, Denmark.
Miriam GötteUniversity Hospital Essen, West German Cancer Center, Essen, Germany.
Lidija KitanovskiUniversity Medical Center Ljubljana, Division of Pediatrics, Department of Haematooncology, Ljubljana, Slovenia.
Barbara KondaForma 3D Ltd., Forma 3D, Ljubljana, Slovenia.
Alejandro LuciaDepartment of Sports Sciences, Faculty of Medicine, Health and Sports, Universidad Europea de Madrid, Madrid, Spain.
Rodolf MongondryCentre de Lutte Contre le Cancer Léon Bérard, Prevention Cancer Environment Department, Lyon, France.
Katie RizviYouth Cancer Europe, Cluj-Napoca, Romania.
Hanne Bækgaard LarsenUniversity Hospital Copenhagen, Rigshospitalet, Department of Clinical Medicine, Copenhagen, Denmark.
Nikolai BauerHeidelberg University Hospital and National Center for Tumor Diseases, a partnership between DKFZ and University Medical Center Heidelberg, Department of Medical Oncology, Working Group Exercise Oncology, Heidelberg, Germany.
Ronja BellerClinic of Pediatrics III, Hematology and Oncology, West German Cancer Center University Hospital Essen, Essen, Germany.
Carmen Fiuza-LucesHospital 12 de Octubre Research Institute, 'imas12, Physical Activity and Health Laboratory, Madrid, Spain.
Gabriele GaußClinic of Pediatrics III, Hematology and Oncology, West German Cancer Center University Hospital Essen, Essen, Germany.
Mareike KühnUniversity Medical Center of the Johannes Gutenberg-University Mainz, Childhood Cancer Center Mainz, Mainz, Germany.
Tommaso P MoriggiFondazione Monza e Brianza per Il Bambino e La Sua Mamma, Centro Maria Letizia Verga, Monza, Italy.
Olivia PérolCentre de Lutte Contre le Cancer Léon Bérard, Prevention Cancer Environment Department, Lyon, France.
Franziska OlivierHeidelberg University Hospital and National Center for Tumor Diseases, a partnership between DKFZ and University Medical Center Heidelberg, Department of Medical Oncology, Working Group Exercise Oncology, Heidelberg, Germany.
Domen RavnikUniversity Medical Center Ljubljana, Division of Pediatrics, Department of Haematooncology, Ljubljana, Slovenia.
Meta RovanUniversity Medical Center Ljubljana, Division of Pediatrics, Department of Haematooncology, Ljubljana, Slovenia.
Elena Santana-SosaDepartment of Sports Sciences, Faculty of Medicine, Health and Sports, Universidad Europea de Madrid, Madrid, Spain.
Milica StefanovićUniversity Medical Center Ljubljana, Division of Pediatrics, Department of Haematooncology, Ljubljana, Slovenia.
Peter WrightOxford Brookes University, School of Sport, Nutrition and Allied Health Professions, Oxford, United Kingdom.
William ZardoPediatric Oncology Unit, Fondazione IRCCS Istituto nazionale dei Tumori, Milano, Italy.
Francesca LanfranconiFondazione Monza e Brianza per Il Bambino e La Sua Mamma, Centro Maria Letizia Verga, Monza, Italy.
Joachim WiskemannHeidelberg University Hospital and National Center for Tumor Diseases, a partnership between DKFZ and University Medical Center Heidelberg, Department of Medical Oncology, Working Group Exercise Oncology, Heidelberg, Germany.
Joerg FaberUniversity Medical Center of the Johannes Gutenberg-University Mainz, Childhood Cancer Center Mainz, Mainz, Germany.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Exercise therapy is increasingly recognized as an integral component of supportive care in pediatric oncology. However, exercise programs are not yet widely implemented nor established as standard care across Europe. The aim of this consensus statement is to provide practical recommendations for the implementation of exercise as a therapy in pediatric oncology, based on consensus from multi-disciplinary experts within the FORTEe project, funded by the European Union's Horizon 2020 research and innovation programme. Methods: The FORTEe trial (NCT05289739) is a multicenter, randomized controlled trial aiming to investigate the effects of a structured exercise intervention in children and adolescents undergoing cancer treatment. Based on this collaborative experience, this expert-informed consensus statement, derived from a structured multinational trial preparation and implementation process, presents resource-adapted recommendations to support multidisciplinary teams in initiating, expanding and sustaining precision-based exercise programs in pediatric oncology. Results: The recommendations address key domains relevant to implementation, including human resources and interprofessional role distribution, staff training, medical clearance and reasons for adapting exercise, monitoring of exercise-related complications, practical delivery of exercise programs across diverse resource settings, as well as legal and regulatory requirements. Conclusion: These recommendations offer practical, context-specific guidance to support the stepwise implementation of exercise therapy in heterogeneous pediatric oncology settings. They are intended to facilitate the safe and sustainable integration of exercise as a therapy into routine childhood cancer care, regardless of local resource availability.

Indexed as

childhood cancerexercise implementationexercise interventionpediatric oncologyphysical activitysupportive caretraining

Identifiers

PMID42488125
PMCPMC13389839

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.