ArticleJuntendo medical journal2026
Endotoxin-induced Ferroptosis-associated Leukocyte Injury and DAMP Release in Sepsis: An
Article in Juntendo medical journal, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- Granulomonocytapheresis for Sepsis: Mechanistic Rationale, Therapeutic Potential, and Potential Concerns in Thromboinflammatory Critical Illness.Juntendo medical journal · 2026Review
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Sepsis is characterized by dysregulated inflammation and thromboinflammation in which regulated cell death and damage-associated molecular patterns (DAMPs) contribute to organ injury. Ferroptosis has recently emerged as a potential mechanism of inflammatory cell injury in sepsis. Objective: To investigate ferroptosis-associated leukocyte injury and inflammatory lytic cell death in an Methods: Rat peritoneal leukocytes were stimulated with lipopolysaccharide (LPS; 0.4 mg/mL). Intracellular, mitochondrial, and lysosomal Fe Results: LPS stimulation induced marked leukocyte injury characterized by membrane rupture, cytoplasmic collapse, and extracellular dispersion of cellular contents. Fluorescence imaging demonstrated increased intracellular, mitochondrial, and lysosomal Fe Conclusions: Ferroptosis-associated iron accumulation, DAMP release, and overlapping inflammatory cell death phenotypes may collectively contribute to thromboinflammation and organ injury in sepsis.
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