Evidence map›Paper›PMID 42487986›Full record

ArticlePediatric gastroenterology, hepatology & nutrition2026

Is Necrotizing Enterocolitis Totalis a Distinct Disease Process?

Pengjian Zou, Wenhai Fang, Peizhi Zhao, Junjian Lv, Tulian Lin, Zhe Wang, Wenjie Luo, Peipei Wu, Wei Zhong, Qiuming He

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In one paragraph

Article in Pediatric gastroenterology, hepatology & nutrition, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Pengjian ZouDepartment of Neonatal Surgery, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangzhou, China.ORCID https://orcid.org/0009-0005-4443-3515
Wenhai FangDepartment of Pediatric Surgery, The Maternal and Children Health Care Hospital (Huzhong Hospital) of Huadu, Guangzhou, China.ORCID https://orcid.org/0009-0005-1260-9926
Peizhi ZhaoDepartment of Neonatal Surgery, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangzhou, China.ORCID https://orcid.org/0009-0003-9779-1514
Junjian LvDepartment of Neonatal Surgery, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangzhou, China.ORCID https://orcid.org/0009-0005-9308-0875
Tulian LinDepartment of Neonatal Surgery, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangzhou, China.ORCID https://orcid.org/0000-0003-0034-1772
Zhe WangDepartment of Neonatal Surgery, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangzhou, China.ORCID https://orcid.org/0000-0001-9116-9722
Wenjie LuoDepartment of Neonatal Surgery, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangzhou, China.ORCID https://orcid.org/0009-0003-3809-4903
Peipei WuDepartment of Pediatric Surgery, The Maternal and Children Health Care Hospital (Huzhong Hospital) of Huadu, Guangzhou, China.ORCID https://orcid.org/0009-0004-4879-6025
Wei ZhongDepartment of Neonatal Surgery, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangzhou, China.ORCID https://orcid.org/0000-0002-0637-3743
Qiuming HeDepartment of Neonatal Surgery, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangzhou, China.ORCID https://orcid.org/0000-0002-0365-1648

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Purpose: This study aimed to characterize the clinical features of necrotizing enterocolitis totalis (NEC-T) in infants compared with NEC non-totalis (NEC-non-T) and to identify associated risk factors, thereby providing insights into its management for clinicians and parents. Methods: A retrospective study was conducted at the Guangzhou Women and Children's Medical Centre and included infants with Bell's Stage II or III NEC from January 2015 to March 2021. Infants were divided into NEC-T and NEC-non-T groups based on intraoperative findings. Clinical data were collected and compared between the two groups. Logistic regression was used to identify independent risk factors for NEC-T. Results: Among 195 infants who underwent surgery for NEC, 30 (15.4%) had NEC-T. Significant differences were observed in gestational age, time from onset to surgery (8 hours vs. 46 hours, Conclusion: NEC-T in neonates is characterized by sudden onset, rapid progression, and high mortality. NRDS, ventilatory support after birth, bacteremia, transfusion, increased ventilatory support, and PVG significantly increased the risk of NEC-T. Aggressive surgical decision-making may be a crucial approach to improving survival rates in patients with NEC-T.

Indexed as

Clinical characteristicsNecrotizing enterocolitis totalisPrognosisRisk factors

Identifiers

PMID42487986
PMCPMC13388025

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.