Evidence map›Paper›PMID 42487955›Full record

ArticleFrontiers in medicine2026

Hemoglobin glycation index and short-term mortality in sepsis: a retrospective cohort study with external validation.

Qianping Zhang, Yan Zhang, Xuemeng Li, Xinyi Tian, Zhijun Meng, Jin Zhang, Jie Weng, Kaifan Lin, Bihuan Cheng, Yuqiang Gong and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Qianping Zhang *Department of Anesthesia and Critical Care, The Second Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, China.
Yan Zhang *NHC Key Lab of Reproduction Regulation, Shanghai Engineering Research Center of Reproductive Health Drug and Devices, Shanghai Institute for Biomedical and Pharmaceutical Technologies, Shanghai, China.
Xuemeng Li *The Second Clinical Medical College of Wenzhou Medical University, Wenzhou, Zhejiang, China.
Xinyi TianDepartment of Anesthesia and Critical Care, The Second Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, China.
Zhijun MengDepartment of Anesthesia and Critical Care, The Second Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, China.
Jin ZhangDepartment of Anesthesia and Critical Care, The Second Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, China.
Jie WengDepartment of General Practice, The Second Affiliated Hospital of Wenzhou Medical University, Wenzhou, China.
Kaifan LinDepartment of Anesthesia and Critical Care, The Second Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, China.
Bihuan ChengDepartment of Anesthesia and Critical Care, The Second Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, China.
Yuqiang Gong *Department of Anesthesia and Critical Care, The Second Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, China.
Ye Gao *Department of Anesthesia and Critical Care, The Second Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: The hemoglobin glycation index (HGI) reflects interindividual variability in hemoglobin glycation beyond average glycemic exposure. Although stress-related dysglycemia is common in sepsis, the prognostic relevance of HGI in critically ill patients with sepsis remains unclear. Methods: We conducted a retrospective cohort study using the MIMIC-IV database ( Results: In the primary cohort, the 28-, 60-, and 90-day mortality rates were 23.25, 27.69, and 30.00%, respectively. Non-survivors exhibited significantly lower HGI levels than survivors ( Conclusion: Higher HGI was associated with lower short-term mortality in this retrospective cohort of critically ill patients with sepsis, with the strongest evidence observed for 28-day mortality. These findings suggest that HGI may provide prognostic information during the early phase of sepsis. Prospective studies are needed to validate these findings and determine their clinical utility.

Indexed as

critical carehemoglobin glycation indexmortalityprognosissepsis

Identifiers

PMID42487955
PMCPMC13388289

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.