ArticleFrontiers in human neuroscience2026
Effects of motor activity versus cognitive demand on asymmetries in EEG frequency bands and their relation to handedness.
Article in Frontiers in human neuroscience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05155397 (The Dortmund Vital Study), which is not on this map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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The Dortmund Vital Study: Impact of Biological and Lifestyle Factors on Cognitive Performace and Work Ability Across the Lifespan. An Interdisciplinary, Cross-sectional and Longitudinal Study
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9 authors.
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Abstract
Introduction: Electroencephalography (EEG) is commonly used in neuroscience to study cognitive and emotional processes, often showing functional lateralization. Alpha asymmetries are frequently interpreted as a reverse marker of functional asymmetries in cognitive activation. However, the role of motor activity versus cognitive demands in driving EEG asymmetries remains unclear. Methods: To explore this, we analyzed resting-state and task-based EEG asymmetry from 610 healthy adults (ages 20-70) from the Dortmund Vital Study (ClinicalTrials.gov: NCT05155397). Participants completed three tasks with increasing hand involvement and cognitive demands: Psychomotor Vigilance, Simon, and Stroop tasks. Results: Timepoint (pre-stimulus vs. post-stimulus vs. resting-state) had the strongest impact, especially in the alpha and theta bands, with notable differences between resting-state and task-related asymmetries. Non-right-handers exhibited more dynamic shifts in asymmetry, while right-handers showed more stable lateralization patterns. Correlations between frequency bands, electrode pairs, and tasks revealed strong interhemispheric coupling in frontal and weaker coupling in central regions. Frontal post-stimulus asymmetry correlated more strongly than resting-state or pre-stimulus. Discussion: Findings suggest that EEG asymmetry is a dynamic process influenced by cognitive and/or motor activity and perceptual processes mediated by frontoparietal circuits, with implications for interpreting EEG biomarkers in both research and clinical settings. This study offers reference standards in EEG asymmetry research.
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