Evidence map›Paper›PMID 42487740›Full record

ArticleComputational and structural biotechnology journal2026

Analyzing DNA Replication Fork Stability and Collapse Using Chromatin Fiber Analysis and the R-ODD-BLOBS Program.

Kerenza Cheng, Kazeera Aliar, Roozbeh Manshaei, Susan L Forsburg, Ali Mazalek, Sarah A Sabatinos

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Computational and structural biotechnology journal, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors.

Kerenza ChengMolecular Science Graduate Program, Yeates School of Graduate and Postdoctoral Studies, Toronto Metropolitan University, Toronto, ON M5B 2K3, Canada.ORCID https://orcid.org/0009-0009-8149-5845
Kazeera AliarDepartment of Chemistry and Biology, Toronto Metropolitan University, Toronto, ON M5B 2K3, Canada.ORCID https://orcid.org/0000-0003-1499-1020
Roozbeh ManshaeiSynaesthetic Media Lab, The Creative School, Toronto Metropolitan University, Toronto, ON M5B 2K3, Canada.ORCID https://orcid.org/0000-0001-9336-5831
Susan L ForsburgDepartment of Molecular and Cellular Biosciences, University of Southern California, Los Angeles, CA 90089, USA.ORCID https://orcid.org/0000-0002-4895-8598
Ali MazalekMolecular Science Graduate Program, Yeates School of Graduate and Postdoctoral Studies, Toronto Metropolitan University, Toronto, ON M5B 2K3, Canada.ORCID https://orcid.org/0000-0003-0293-5435
Sarah A SabatinosMolecular Science Graduate Program, Yeates School of Graduate and Postdoctoral Studies, Toronto Metropolitan University, Toronto, ON M5B 2K3, Canada.ORCID https://orcid.org/0000-0002-0685-7668

Funding

Genetic Analysis of MSM Protein Function in S. PombeR01GM059321 · NIGMS · UNIVERSITY OF SOUTHERN CALIFORNIA · PI FORSBURG, SUSAN L · 1999 to 2012
$4.7M
NIGMS NIH HHS R01 GM059321
6 · The paper itself

Abstract

We describe the anatomy of replication forks by detecting proteins associated with DNA replication (Cdc45 and RPA), DNA damage (H2A.X), and DNA repair (Rad51) relative to tracts of synthesized, 5'-bromodeoxyuridine (BrdU)-labeled DNA on chromatin fiber images. These fibers track pixel intensity and positional data, which are analyzed using our program: R-ODD-BLOBS (One Dimensional Data Boolean Logic Operations Binning System in the programming language R). We studied the effect of threshold and signal smoothing for BrdU and protein tracts following hydroxyurea in wild type fission yeast (

Identifiers

PMID42487740
PMCPMC13389046

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.