ArticleSchizophrenia bulletin open2026
The Lived Experience of Cognitive Impairment Associated With Schizophrenia: A Conceptual Model.
Article in Schizophrenia bulletin open, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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14 authors.
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Abstract
Background: Cognitive impairment associated with schizophrenia (CIAS) has a substantial impact on people living with the condition. We aimed to update a 2012 conceptual model of CIAS with consideration of lived experience using insights from multinational cohorts of healthcare stakeholders and people living with schizophrenia. Methods: To update the 2012 conceptual model, we used insights from a targeted literature review, concept elicitation interviews with adults living with schizophrenia ( Results: Six relevant articles were identified that reported 52 CIAS signs and symptoms and 33 impacts of CIAS. CIAS domains highlighted in the concept elicitation interviews as affecting participants' lives included attention (92% of participants), social cognition (84%), processing speed (80%), and memory (76%). Advisory board participants reported impacts of CIAS on daily life and independent living, including career goals and relationships. CONNEX-X exit interviewees reported memory problems (51% of participants), difficulties in learning new things (46%), and concentration difficulties (43%). These insights were used to expand the CIAS model and provide more nuance and granularity. Conclusion: The findings of this study highlight the substantial burden of CIAS on the daily lives of people living with schizophrenia and the impact on their quality of life. A modern CIAS conceptual model is important for the assessment of cognitive impairment in both clinical trials and clinical practice.
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