ArticleAmerican journal of clinical and experimental immunology2026
Comparison of allergen types and complete blood count in pediatric allergic rhinitis.
Article in American journal of clinical and experimental immunology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundAllergic rhinitis (AR) is a highly prevalent immunoglobulin E (IgE)-mediated disease that significantly impacts quality of life. While hematological parameters (complete blood count [CBC]) are linked to inflammation in adult AR, their relevance to pediatric populations remains unclear. This study aimed to characterize allergen sensitization profiles, CBC parameters, and immunoglobulin features in pediatric AR patients across demographic subgroups (sex, age, disease duration).
methodsA retrospective study included 253 children with AR (aged 3-12 years; 176 males, 77 females) who tested positive for specific IgE (sIgE) to one or more inhalant allergens (≥ 0.35 IU/mL). Demographics, symptom scores (nasal/ocular), family history, sIgE, CBC, total immunoglobulin E (tIgE), immunoglobulin A (IgA), immunoglobulin G (IgG), immunoglobulin M (IgM), and complement component 4 (C4) were assessed. Statistical analyses were performed to compare groups based on sex, age (preschool vs. school-age), and disease duration, and to examine correlations between parameters and symptom scores.
resultsHouse dust mites (HDM) (including
conclusionHDM are the primary allergens in the pediatric AR population in Guangzhou. Significant sex-, age-, and duration-related differences exist in sensitization patterns and immune and CBC profiles. After rigorous statistical control for multiple comparisons, only total IgE, absolute basophil count, and eosinophil percentage correlated significantly with symptom severity, highlighting their potential as accessible biomarkers for assessing disease activity.
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