ArticleFrontiers in microbiology2026
Genomic-island cassette architecture provides interpretable signal for exploratory classification of poultry-associated
Article in Frontiers in microbiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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1 citing paper in PubMed.
- Genomic-island cassette architecture provides interpretable signal for exploratory classification of poultry-associatedFrontiers in microbiology · 2026Article
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3 authors.
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Abstract
Background: Methods: We tested whether GI (genomic island)-anchored cassette organization provides signal for distinguishing pathogenic from commensal poultry-associated Results: The cassette-summary Random Forest model achieved an area under the receiver operating characteristic curve (AUROC) of 0.918 ± 0.067, outperforming GI burden (AUROC 0.791 ± 0.050) and assembly-quality (AUROC 0.743 ± 0.015) baselines and performing similarly to a corrected AMR gene-content baseline (AUROC 0.906 ± 0.044). A conservative GI-restricted gene product presence/absence proxy achieved AUROC 0.887 ± 0.083, while a full joint-run pangenome GPA baseline remains a necessary future benchmark. Fragmentation-controlled analyses confirmed cassette signal remained informative after quality filtering (AUROC 0.827 in assemblies with ≤50 contigs; Conclusion: These results suggest that cassette architecture captures signal consistent with biologically meaningful genomic organization beyond bulk island burden and supports its use as an interpretable exploratory representation for surveillance-oriented analysis of poultry-associated
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