ArticleJournal of pediatric gastroenterology and nutrition2026
Reevaluating the rule of two's: Age and epidemiological variations in Meckel's diverticulum.
Article in Journal of pediatric gastroenterology and nutrition, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
objectiveTo evaluate the clinical characteristics, diagnostic modalities, and age-related variation of Meckel's diverticulum (MD) using data from a nationwide pediatric inpatient database and a single-center institutional cohort.
methodsThe Kids' Inpatient Database (KID) for 2016 and 2019 was queried for patients with a principal diagnosis of MD. We additionally conducted a retrospective review of patients hospitalized with a primary diagnosis of MD at our institution over a 20-year period (January 1, 2005-May 1, 2025). Diagnosis was confirmed by surgical findings and pathology.
resultsA total of 1004 patients with a primary diagnosis of MD were identified in KID. More than half were diagnosed after 5 years of age (n = 648, 64.8%). Similarly, among 147 patients identified in the single-center cohort, 63.2% (n = 93) were diagnosed after 5 years of age. Within this single-center cohort, patients ≤5 years more commonly presented with painless rectal bleeding (38.9%, p = 0.017) and underwent Meckel's scintigraphy more frequently (48.1%, p < 0.005). In contrast, patients >5 years more often presented with abdominal pain (61.3%) or vomiting (54.8%) and were more likely to undergo abdominal computed tomography (68.9%, p < 0.0001). Length of stay (LOS) was longer in patients <5 years and shortest in those >15 years (p = 0.04).
conclusionMore than half of pediatric patients with MD are diagnosed after 5 years of age. Presentation, LOS, and imaging patterns vary by age, with younger children more often presenting with bleeding and older children with obstructive symptoms and greater CT detection.
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