ArticleVeterinary clinical pathology2026
Evaluation of an Immunoturbidometric Assay for Measurement of Total Adiponectin Concentration in Equine Serum Samples.
Article in Veterinary clinical pathology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- Echocardiographic characteristics and evidence of ventricular remodeling in subclinical insulin-dysregulated Warmblood horses.Journal of veterinary internal medicine · 2026Article
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Authors and funding
6 authors.
Funding
Abstract
backgroundTotal adiponectin (TA) is a marker of metabolic health in equids, with values below a critical decision point of < 7.9 μg/mL conferring increased risk of laminitis.
objectivesTo evaluate an IT assay to measure serum [TA] in equids and to assess its correlation with [high molecular weight adiponectin] (HMWA) measured by ELISA.
methodsTotal serum adiponectin concentrations from 207 adult horses were measured using both an IT assay for TA and HMWA using a previously validated ELISA assay. Data were analyzed using Spearman correlation and Passing-Bablok regression. Intra- and inter-assay precision, linearity, lower limit of quantification (LLoQ), and freeze-thaw stability were assessed for the [TA] assay.
resultsMean (range) intra-assay coefficient of variation (CV%) was 2.3% (1.8%-2.8%); inter-assay, across-day CV% was 3.3% (3.25%-3.4%), and across reagent lot CV was 11.7% (9.0%-17.9%). Mean recovery upon dilution was 133.7% (122.6%-140.6%), and LLoQ 1.3 μg/mL. The median CV for 5 freeze-thaw cycles was 3.0% (range 1.0%-3.0%) with a median change in concentration of -11% (range -[9.9-17.1]%). A strong correlation between [TA] and [HMWA] is observed (ρ = 0.90 [95% confidence interval 0.86-0.92], p < 0.001), although in 18% of samples, [HMWA] > [TA].
conclusionsThe turbidimetric immunoassay is sufficiently precise and reliable for measurement of [TA] in equids, especially around the critical decision point, and LLoQ was below the lowest clinical cut-off value. [TA] overall correlated well with [HMWA] in this population, although instances of higher [HMWA] than [TA] were noted at high [HMWA].
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