ArticlePigment cell & melanoma research2026
A Recessive oca2 Mutation Underlies Albinism in Xiphophorus Fish.
Article in Pigment cell & melanoma research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Corrections and comments
- Update ofA Recessive2025
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6 authors.
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Abstract
Oculocutaneous albinism (OCA) is a group of genetic disorders characterized by impaired melanin production, leading to reduced pigmentation in the skin, hair, and eyes. Xiphophorus, a genus of small freshwater fish, has been a pivotal model organism in pigmentation disorder research, providing key findings in the genetic pathways governing physiological and pathological pigment cell biology. Leveraging the well-established research framework provided by Xiphophorus, we have identified a spontaneously occurring albinism phenotype in swordtail fish Xiphophorus hellerii. Genetic mapping of albino fish showed that albinism is associated with a recessive mutation in the oca2 gene. This discovery provides a novel opportunity to explore functions of the oca2 gene in pigment cell differentiation, pigment synthesis, melanosome assembly and transportation function, and amelanotic melanoma development.
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