ArticleNano letters2026
Spontaneous Curvature Sculpts Filament-Vesicle Morphogenesis.
Article in Nano letters, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
Abstract
Membrane-bound filaments are central to cellular morphogenesis, yet how spontaneous curvature regulates filament-membrane coupling under geometric confinement remains unclear. Here we show that spontaneous curvature fundamentally reorganizes filament-membrane morphogenesis in vesicles by biasing the competition between membrane deformation and filament bending. Using a unified curvature-elasticity framework that couples membrane and filament curvature energetics, we construct phase diagrams for vesicles enclosing filament loops and demonstrate that spontaneous curvature selects distinct symmetry-breaking pathways, leading to both continuous and discontinuous morphological transitions. In the rigid-filament limit, we further identify an intrinsic accommodation limit imposed by membrane elasticity together with area and volume conservation, beyond which no mechanically equilibrated configuration exists. These findings establish spontaneous curvature as a powerful design parameter for programming filament-membrane morphogenesis in biological and synthetic systems.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.