ArticleMagnetic resonance in medicine2026
Improving Fetal Single-Voxel Magnetic Resonance Spectroscopy With Spectral Registration.
Article in Magnetic resonance in medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
purposeTo evaluate whether spectral registration improves spectral quality and quantification reliability in in vivo single-voxel fetal brain MRS:
methodsFourteen fetal PRESS datasets were acquired at 3 T at TE = 35 ms and TE = 135 ms. Raw data were processed with eddy-current phase correction, coil combination, spectral registration, and outlier rejection; spectra processed with eddy-current correction alone were treated as uncorrected. Corrected and uncorrected spectra were compared using LCModel quality metrics (SNR, FWHM, and CRLB), metabolite concentrations and ratios, and qualitative spectral assessment.
resultsSpectral registration improved spectral appearance, with sharper peaks and reduced line broadening. SNR increased and FWHM decreased significantly at both echo times. At TE = 35 ms, pooled CRLB values decreased significantly after correction, and more estimates met CRLB thresholds, most notably for CRLB ≤ 50; corresponding CRLB improvements at TE = 135 ms were limited. No metabolite concentration comparison remained significant after false-discovery-rate correction, and only Glx/tCho at TE = 35 ms remained significant among metabolite ratios.
conclusionSpectral registration improved fetal MRS spectral quality and modestly improved quantification reliability, with the clearest benefit at short TE. These findings support spectral registration as a practical retrospective processing step for motion-prone fetal MRS.
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