ReviewKnee surgery & related research2026
Diagnostic performance of the platelet-to-lymphocyte ratio (PLR) for periprosthetic joint infection after total hip and knee arthroplasty: a systematic review and meta-analysis.
Review in Knee surgery & related research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundResearch has investigated the function of biomarkers, such as the platelet-lymphocyte ratio (PLR), in identifying periprosthetic joint infection (PJI) after total hip arthroplasty (THA) and total knee arthroplasty (TKA). This study aimed to conduct an updated systematic review and meta-analysis in order to assess the diagnostic efficacy of PLR for PJI.
methodsReviews of databases including PubMed, Scopus, and Web of Science were conducted to identify studies related to the use of PLR in diagnosing PJI. The evaluations covered the diagnostic performance of PLR for PJI. Furthermore, because of the significant heterogeneity across the studies, subgroup analyses were conducted focusing on geographic region (China versus other countries), site surgery (unseparated hip and knee versus separated hip and knee), and patient numbers (more than 200 versus less than 200).
resultsA total of 4892 TKA and THA patients from 17 studies were included in the meta-analysis. Of the total patients, 1980 (40.5%) were diagnosed with PJI. Diagnostic sensitivity and specificity combined were 0.70 (95% CI 0.62-0.77) and 0.73 (95% CI 0.65-0.79), respectively. Results from the subgroup analysis indicated enhanced sensitivity and specificity concerning geographic differences, surgical site variances, and studies with fewer than 200 patients.
conclusionsPLR demonstrated moderate diagnostic accuracy and could function as an accessible supplementary marker in the evaluation process of PJI; additional research is necessary to establish optimal thresholds and its benefit alongside current diagnostic standards.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.