Evidence map›Paper›PMID 42487032›Full record

ArticleNature neuroscience2026

Cerebral venous blood flow regulates intracerebral pressure and brain clearance via meningeal lymphatic vessels.

Marie-Renee El Kamouh, Myriam Spajer, Ruchith Singhabahu, Anne-Laure Joly Marolany, Kurt A Sailor, Laura Mouton, Diana Doukhi, Sunil Koundal, Tanner Metcalfe, Dominique Langui and 23 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature neuroscience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

33 authors.

Marie-Renee El KamouhParis Brain Institute, Université Pierre et Marie Curie Paris 06, INSERM UMRS 1127, Sorbonne Université, Paris, France.
Myriam Spajer *Paris Brain Institute, Université Pierre et Marie Curie Paris 06, INSERM UMRS 1127, Sorbonne Université, Paris, France.ORCID http://orcid.org/0000-0001-7483-2983
Ruchith Singhabahu *Paris Brain Institute, Université Pierre et Marie Curie Paris 06, INSERM UMRS 1127, Sorbonne Université, Paris, France.ORCID http://orcid.org/0009-0002-1242-1534
Anne-Laure Joly MarolanyParis Brain Institute, Université Pierre et Marie Curie Paris 06, INSERM UMRS 1127, Sorbonne Université, Paris, France.
Kurt A SailorInstitut Pasteur, Université de Paris, CNRS UMR 3571, Paris, France.
Laura MoutonParis Brain Institute, Université Pierre et Marie Curie Paris 06, INSERM UMRS 1127, Sorbonne Université, Paris, France.ORCID http://orcid.org/0000-0002-6698-3412
Diana DoukhiUniversité Paris Cité, Department of Neurology, AP-HP, Hôpital Lariboisière, FHU NeuroVasc, Paris, France.ORCID http://orcid.org/0009-0008-9359-0471
Sunil KoundalDepartment of Anesthesiology, Yale School of Medicine, New Haven, CT, USA.
Tanner MetcalfeDepartment of Anesthesiology, Yale School of Medicine, New Haven, CT, USA.
Dominique LanguiParis Brain Institute, Université Pierre et Marie Curie Paris 06, INSERM UMRS 1127, Sorbonne Université, Paris, France.
Abel GrineParis Brain Institute, Université Pierre et Marie Curie Paris 06, INSERM UMRS 1127, Sorbonne Université, Paris, France.
Kevin BoyéParis Cardiovascular Research Center, Université Paris Cité, INSERM U970, Paris, France.
Felipe Saceanu LeserParis Cardiovascular Research Center, Université Paris Cité, INSERM U970, Paris, France.ORCID http://orcid.org/0000-0002-7499-2765
Justus NinnemannInstitut Pasteur, Université de Paris, CNRS UMR 3571, Paris, France.ORCID http://orcid.org/0000-0002-9214-4882
Joshua GottschalkParis Brain Institute, Université Pierre et Marie Curie Paris 06, INSERM UMRS 1127, Sorbonne Université, Paris, France.ORCID http://orcid.org/0009-0008-2413-443X
Cyrus SadeghiParis Brain Institute, Université Pierre et Marie Curie Paris 06, INSERM UMRS 1127, Sorbonne Université, Paris, France.
Han XuDepartment of Neurology, Yale University School of Medicine, New Haven, CT, USA.
Ligia Simoes Braga BoisserandDepartment of Neurology, Yale University School of Medicine, New Haven, CT, USA.
David AkbarParis Brain Institute, Université Pierre et Marie Curie Paris 06, INSERM UMRS 1127, Sorbonne Université, Paris, France.
Jerome Van WassenhoveParis Brain Institute, Université Pierre et Marie Curie Paris 06, INSERM UMRS 1127, Sorbonne Université, Paris, France.
Anthony RuzeParis Brain Institute, Université Pierre et Marie Curie Paris 06, INSERM UMRS 1127, Sorbonne Université, Paris, France.
Amelle NasriParis Brain Institute, Université Pierre et Marie Curie Paris 06, INSERM UMRS 1127, Sorbonne Université, Paris, France.
Marie-Charlotte BourrienneOptimisation Thérapeutique en Neuropsychopharmacologie, INSERM U1144, Paris, France.
Elora BuscherParis Brain Institute, Université Pierre et Marie Curie Paris 06, INSERM UMRS 1127, Sorbonne Université, Paris, France.
Young-Kwon HongDepartment of Surgery, Beth Israel Deaconess Medical center, Harvard Medical School, Boston, MA, USA.
Mikael MazighiOptimisation Thérapeutique en Neuropsychopharmacologie, INSERM U1144, Paris, France.
Pierre-Marie LledoInstitut Pasteur, Université de Paris, CNRS UMR 3571, Paris, France.ORCID http://orcid.org/0000-0002-8156-7003
Helene BenvenisteDepartment of Anesthesiology, Yale School of Medicine, New Haven, CT, USA.ORCID http://orcid.org/0000-0002-2887-6667
Mathieu SantinParis Brain Institute, Université Pierre et Marie Curie Paris 06, INSERM UMRS 1127, Sorbonne Université, Paris, France.
Anne EichmannParis Cardiovascular Research Center, Université Paris Cité, INSERM U970, Paris, France.
Stéphane LehericyParis Brain Institute, Université Pierre et Marie Curie Paris 06, INSERM UMRS 1127, Sorbonne Université, Paris, France.
Jean-Léon ThomasParis Brain Institute, Université Pierre et Marie Curie Paris 06, INSERM UMRS 1127, Sorbonne Université, Paris, France.ORCID http://orcid.org/0000-0003-3397-0292
Stéphanie LenckParis Brain Institute, Université Pierre et Marie Curie Paris 06, INSERM UMRS 1127, Sorbonne Université, Paris, France. stephanie.lenck@icm-institute.org.ORCID http://orcid.org/0000-0003-4952-8490

Funding

Structural and Functional Studies of the Uterine LymphaticsR01HL141857 · NHLBI · UNIVERSITY OF SOUTHERN CALIFORNIA · PI Young-Kwon Hong · 2018 to 2026
$3.6M
NHLBI NIH HHS R01 HL141857
6 · The paper itself

Abstract

Idiopathic intracranial hypertension (IIH) is characterized by elevated intracranial pressure and dural venous sinus stenoses, which can be relieved by venous stenting. Here we investigated whether venous blood flow may play a role in controlling brain pressure. Using magnetic resonance imaging in patients with IIH and healthy controls, we identified that dural venous stenoses in IIH were associated with alterations of the perivenous fluid pattern and brain edema. We developed a mouse model of jugular vein ligation (JVL), which developed transient intracerebral hypertension, brain edema and impaired brain clearance, along with defective meningeal lymphatic vessels (MLVs). MLV depletion increased intracerebral pressure in control and JVL mice, but only MLV-deficient ligated mice failed to restore brain fluid clearance. These findings implicate MLVs in the control of intracerebral pressure and establish the dural venous sinuses as critical platforms where venous flow directs MLVs to ensure brain fluid clearance.

Indexed as

BrainCerebral VeinsCerebrovascular CirculationIntracranial PressureLymphatic VesselsMeningesPseudotumor CerebriAnimalsBrain EdemaDisease Models, AnimalFemaleHumansJugular VeinsMagnetic Resonance ImagingMaleMice

Identifiers

PMID42487032
PMCPMC13533833

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.