Evidence map›Paper›PMID 42487017›Full record

ReviewJournal of molecular histology2026

Research progresses on the regulatory roles of microRNAs in radiation-induced pulmonary fibrosis.

Min Zhu, Haowei Li, Rui Chen, Jianming Cai, Tao Wang, Changjing Zuo

Abstract readReview
PubMed Publisher
In one paragraph

Review in Journal of molecular histology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Min ZhuDepartment of Nuclear Medicine, the First Affiliated Hospital of Naval Medical University, Shanghai, 200433, China.
Haowei LiDepartment of Nuclear Medicine, the First Affiliated Hospital of Naval Medical University, Shanghai, 200433, China.
Rui ChenDepartment of Nuclear Medicine, the First Affiliated Hospital of Naval Medical University, Shanghai, 200433, China.
Jianming CaiSchool of Public Health and Management, Wenzhou Medical University, Wenzhou, 325035, Zhejiang, China.
Tao WangDepartment of Nuclear Medicine, the First Affiliated Hospital of Naval Medical University, Shanghai, 200433, China. wangtao2086@smmu.edu.cn.
Changjing ZuoDepartment of Nuclear Medicine, the First Affiliated Hospital of Naval Medical University, Shanghai, 200433, China. cjzuo@smmu.edu.cn.

Funding

the Guhai Plan in the 14th Five-Year Plan Period of the First Affiliated Hospital of Naval Medical University Grant No. GH145-22
6 · The paper itself

Abstract

Radiation-induced pulmonary fibrosis (RIPF) is a chronic fibrotic lung disease triggered by ionizing radiation exposure and is characterized by abnormal epithelial-mesenchymal transition (EMT), fibroblast proliferation and activation, and excessive extracellular matrix (ECM) deposition. As a late-stage pulmonary complication of radiation exposure, RIPF lacks effective clinical interventions. Although nintedanib and pirfenidone are approved antifibrotic drugs for idiopathic pulmonary fibrosis (IPF), their efficacy against RIPF remains insufficiently validated. The precise pathogenesis of RIPF remains incompletely understood; however, accumulating evidence highlights the critical regulatory role of epigenetic modifications, particularly microRNAs (miRNAs), in the development and progression of RIPF. Here, we summarize the regulatory mechanisms of miRNAs in RIPF, and highlight their clinical potential and current research challenges, aiming to advance miRNA-related research in RIPF.

Indexed as

Gene Expression RegulationMicroRNAsPulmonary FibrosisAnimalsEpigenesis, GeneticEpithelial-Mesenchymal TransitionHumansMicroRNAsEpithelial-mesenchymal transition (EMT)Fibroblast activationIonizing radiationmiRNARadiation-induced pulmonary fibrosis (RIPF)

Identifiers

PMID42487017

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.