Evidence map›Paper›PMID 42486984›Full record

ArticleNature2026

Precise DNA base editing using AlphaFold3-based contact modelling.

Haowei Meng, Zhixin Lei, Yongchang Yan, Liren Wang, Sihan Zhang, Xichen Rao, Chuyun Shao, Xiaoting Zhang, Ke Chen, Lei Yang and 12 more

Abstract read
PubMed Publisher
In one paragraph

Article in Nature, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

22 authors.

Haowei Meng *State Key Laboratory of Gene Function and Modulation Research, School of Life Sciences, Peking University, Beijing, China.ORCID http://orcid.org/0000-0001-9695-5060
Zhixin Lei *Peking-Tsinghua Center for Life Sciences, Peking University, Beijing, China.ORCID http://orcid.org/0000-0002-1221-487X
Yongchang Yan *Peking-Tsinghua Center for Life Sciences, Peking University, Beijing, China.
Liren Wang *Shanghai Frontiers Science Center of Genome Editing and Cell Therapy, Shanghai Key Laboratory of Regulatory Biology, Institute of Biomedical Sciences and School of Life Sciences, East China Normal University, Shanghai, China.
Sihan Zhang *Peking University-Tsinghua University-National Institute Biological Sciences (PTN) Joint Graduate Program, Academy for Advanced Interdisciplinary Studies, Peking University, Beijing, China.ORCID http://orcid.org/0009-0004-4886-6054
Xichen Rao *State Key Laboratory of Gene Function and Modulation Research, School of Life Sciences, Peking University, Beijing, China.ORCID http://orcid.org/0000-0003-2450-4521
Chuyun ShaoPeking University-Tsinghua University-National Institute Biological Sciences (PTN) Joint Graduate Program, Academy for Advanced Interdisciplinary Studies, Peking University, Beijing, China.
Xiaoting ZhangPeking University-Tsinghua University-National Institute Biological Sciences (PTN) Joint Graduate Program, Academy for Advanced Interdisciplinary Studies, Peking University, Beijing, China.
Ke ChenPeking-Tsinghua Center for Life Sciences, Peking University, Beijing, China.ORCID http://orcid.org/0009-0009-4402-5297
Lei YangHangzhou Institute of Medicine (HIM), Chinese Academy of Sciences, Hangzhou, China.
Rongrong LiuDepartment of Hematology, The First Affiliated Hospital of Guangxi Medical University, Nanning, China.
Gaohui YangDepartment of Hematology, The First Affiliated Hospital of Guangxi Medical University, Nanning, China.
Ruoyu ShenState Key Laboratory of Gene Function and Modulation Research, School of Life Sciences, Peking University, Beijing, China.
Ruichu GuAI for Science Institute, Beijing, China.
Xinyan WangAI for Science Institute, Beijing, China.ORCID http://orcid.org/0000-0002-3690-2335
Yiya WangState Key Laboratory of Gene Function and Modulation Research, School of Life Sciences, Peking University, Beijing, China.
Suiru LuPeking-Tsinghua Center for Life Sciences, Peking University, Beijing, China.
Zhicong LvState Key Laboratory of Gene Function and Modulation Research, School of Life Sciences, Peking University, Beijing, China.
Bo HePeking University Chengdu Academy for Advanced Interdisciplinary Biotechnologies, Chengdu, China.
Han WenAI for Science Institute, Beijing, China.ORCID http://orcid.org/0000-0003-4680-4218
Dali LiShanghai Frontiers Science Center of Genome Editing and Cell Therapy, Shanghai Key Laboratory of Regulatory Biology, Institute of Biomedical Sciences and School of Life Sciences, East China Normal University, Shanghai, China. dlli@bio.ecnu.edu.cn.ORCID http://orcid.org/0000-0002-0046-8493
Chengqi YiState Key Laboratory of Gene Function and Modulation Research, School of Life Sciences, Peking University, Beijing, China. chengqi.yi@pku.edu.cn.ORCID http://orcid.org/0000-0003-2540-9729

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Achieving high specificity in biochemical transformations is crucial for research and therapeutics. This is particularly important for genome editing, where enhancing tool specificity ensures effective and precise editing outcomes

Indexed as

DNAGene EditingModels, MolecularAdenineAdenosine DeaminaseBase SequenceCRISPR-Associated ProteinsCRISPR-Cas SystemsEscherichia coli ProteinsRNA, Guide, CRISPR-Cas SystemsSubstrate SpecificityAdenineAdenosine DeaminaseCRISPR-Associated ProteinsDNAEscherichia coli ProteinsRNA, Guide, CRISPR-Cas SystemsTadA protein, E coli

Identifiers

PMID42486984

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.