Evidence map›Paper›PMID 42486977›Full record

ArticleNature2026

Genetic background sets the trajectory of experimental cancer evolution.

Sarah J Aitken, Frances Connor, Christine Feig, Tim F Rayner, Margus Lukk, Juliet Luft, Stuart Aitken, Claudia Arnedo-Pac, James F Hayes, Michael D Nicholson and 21 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

31 authors.

Sarah J AitkenCenter of Molecular and Cellular Oncology, Yale Cancer Center, New Haven, CT, USA. sarah.aitken@yale.edu.ORCID http://orcid.org/0000-0002-1897-4140
Frances ConnorCancer Research UK Cambridge Institute, University of Cambridge, Cambridge, UK.ORCID http://orcid.org/0000-0003-2858-9411
Christine FeigCancer Research UK Cambridge Institute, University of Cambridge, Cambridge, UK.
Tim F RaynerCancer Research UK Cambridge Institute, University of Cambridge, Cambridge, UK.
Margus LukkCancer Research UK Cambridge Institute, University of Cambridge, Cambridge, UK.ORCID http://orcid.org/0000-0002-0701-5358
Juliet LuftMedical Research Council Human Genetics Unit, Institute of Genetics and Cancer, University of Edinburgh, Edinburgh, UK.ORCID http://orcid.org/0000-0003-2458-9377
Stuart AitkenMedical Research Council Human Genetics Unit, Institute of Genetics and Cancer, University of Edinburgh, Edinburgh, UK.ORCID http://orcid.org/0000-0003-4867-4568
Claudia Arnedo-PacMedical Research Council Toxicology Unit, University of Cambridge, Cambridge, UK.ORCID http://orcid.org/0000-0002-2037-8487
James F HayesMedical Research Council Human Genetics Unit, Institute of Genetics and Cancer, University of Edinburgh, Edinburgh, UK.ORCID http://orcid.org/0009-0006-0107-5460
Michael D NicholsonSchool of Mathematics and the Maxwell Institute for Mathematical Sciences, University of Edinburgh, Edinburgh, UK.ORCID http://orcid.org/0000-0003-2813-8979
Ailith EwingMedical Research Council Human Genetics Unit, Institute of Genetics and Cancer, University of Edinburgh, Edinburgh, UK.
Vasavi SundaramEuropean Molecular Biology Laboratory, European Bioinformatics Institute, Hinxton, UK.
Jan C VerburgMedical Research Council Human Genetics Unit, Institute of Genetics and Cancer, University of Edinburgh, Edinburgh, UK.ORCID http://orcid.org/0000-0002-3012-3015
John ConnellyMedical Research Council Toxicology Unit, University of Cambridge, Cambridge, UK.
Craig J AndersonMedical Research Council Human Genetics Unit, Institute of Genetics and Cancer, University of Edinburgh, Edinburgh, UK.ORCID http://orcid.org/0000-0002-2832-9313
Mikaela BehmDivision of Regulatory Genomics and Cancer Evolution (B270), German Cancer Research Center (DKFZ), Heidelberg, Germany.
Susan CampbellMedical Research Council Human Genetics Unit, Institute of Genetics and Cancer, University of Edinburgh, Edinburgh, UK.
Maëlle DaunesseEuropean Molecular Biology Laboratory, European Bioinformatics Institute, Hinxton, UK.ORCID http://orcid.org/0000-0003-0350-7790
Vera B KaiserMedical Research Council Human Genetics Unit, Institute of Genetics and Cancer, University of Edinburgh, Edinburgh, UK.
Elissavet KentepozidouEuropean Molecular Biology Laboratory, European Bioinformatics Institute, Hinxton, UK.
Oriol PichInstitute for Research in Biomedicine (IRB Barcelona), The Barcelona Institute of Science and Technology, Barcelona, Spain.ORCID http://orcid.org/0000-0002-1956-1882
Aisling M RedmondCancer Research UK Cambridge Institute, University of Cambridge, Cambridge, UK.ORCID http://orcid.org/0000-0001-9070-1780
Javier Santoyo-LopezEdinburgh Genomics (Clinical), University of Edinburgh, Edinburgh, UK.ORCID http://orcid.org/0000-0003-1988-5059
Inés SentísInstitute for Research in Biomedicine (IRB Barcelona), The Barcelona Institute of Science and Technology, Barcelona, Spain.
Lana TalmaneMedical Research Council Human Genetics Unit, Institute of Genetics and Cancer, University of Edinburgh, Edinburgh, UK.
Liver Cancer Evolution Consortium
Paul FlicekInstitute of Systems Genomics, University of Connecticut, Storrs, CT, USA.
Núria López-BigasInstitute for Research in Biomedicine (IRB Barcelona), The Barcelona Institute of Science and Technology, Barcelona, Spain.ORCID http://orcid.org/0000-0003-4925-8988
Colin A SempleMedical Research Council Human Genetics Unit, Institute of Genetics and Cancer, University of Edinburgh, Edinburgh, UK.
Martin S TaylorMedical Research Council Human Genetics Unit, Institute of Genetics and Cancer, University of Edinburgh, Edinburgh, UK. martin.taylor@ed.ac.uk.ORCID http://orcid.org/0000-0001-7656-330X
Duncan T OdomCancer Research UK Cambridge Institute, University of Cambridge, Cambridge, UK. d.odom@dkfz-heidelberg.de.ORCID http://orcid.org/0000-0001-6201-5599

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Human cancers are heterogeneous

Indexed as

Evolution, MolecularGenetic BackgroundNeoplasmsAnimalsDisease ProgressionEpistasis, GeneticFemaleGenetic Predisposition to DiseaseGenetic VariationHumansMaleMiceMutationSelection, Genetic

Identifiers

PMID42486977
PMCPMC13600922

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.