ArticleNature2026
Prior therapy defines mutation profiles in childhood cancer at relapse.
Abstract read
In one paragraph
Article in Nature, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Article
- The therapy-conditioned host: a state-transition framework for second primary cancer evolution.Frontiers in oncology · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
45 authors.
Mehdi LayeghifardProgram in Genetics and Genome Biology, The Hospital for Sick Children, Toronto, Ontario, Canada.ORCID http://orcid.org/0000-0002-6224-3628
Marcos Díaz-GayDigital Genomics Group, Cancer Genomics Program, Spanish National Cancer Research Center (CNIO), Madrid, Spain.ORCID http://orcid.org/0000-0003-0658-0467
Erik N BergstromDepartment of Cellular and Molecular Medicine, University of California, San Diego, La Jolla, CA, USA.
Mathepan J MahendralingamProgram in Genetics and Genome Biology, The Hospital for Sick Children, Toronto, Ontario, Canada.
Nicholas LightProgram in Genetics and Genome Biology, The Hospital for Sick Children, Toronto, Ontario, Canada.
Sasha BlayProgram in Genetics and Genome Biology, The Hospital for Sick Children, Toronto, Ontario, Canada.ORCID http://orcid.org/0000-0002-5611-2330
Joshua O NashProgram in Genetics and Genome Biology, The Hospital for Sick Children, Toronto, Ontario, Canada.
Nathaniel D AndersonProgram in Genetics and Genome Biology, The Hospital for Sick Children, Toronto, Ontario, Canada.ORCID http://orcid.org/0000-0003-4523-6327
Jessica N AuDepartment of Cellular and Molecular Medicine, University of California, San Diego, La Jolla, CA, USA.ORCID http://orcid.org/0000-0002-5043-2245
Scott DavidsonProgram in Genetics and Genome Biology, The Hospital for Sick Children, Toronto, Ontario, Canada.
Pedro L BallesterProgram in Genetics and Genome Biology, The Hospital for Sick Children, Toronto, Ontario, Canada.ORCID http://orcid.org/0000-0001-9928-2527
Timmy WenProgram in Genetics and Genome Biology, The Hospital for Sick Children, Toronto, Ontario, Canada.
Syed Kashif DaudProgram in Genetics and Genome Biology, The Hospital for Sick Children, Toronto, Ontario, Canada.
Lisa-Monique EdwardProgram in Genetics and Genome Biology, The Hospital for Sick Children, Toronto, Ontario, Canada.ORCID http://orcid.org/0000-0002-1113-7913
S M Ashiqul IslamDepartment of Epidemiology and Biostatistics, College of Integrated Health Sciences, University at Albany-State University of New York, Albany, NY, USA.
Azhar KhandekarDepartment of Cellular and Molecular Medicine, University of California, San Diego, La Jolla, CA, USA.
Burçak OtluDepartment of Health Informatics, Graduate School of Informatics, Middle East Technical University, Ankara, Turkey.ORCID http://orcid.org/0000-0002-4931-7979
Ledia BrungaProgram in Genetics and Genome Biology, The Hospital for Sick Children, Toronto, Ontario, Canada.
Rawan HammadDepartment of Hematology, Faculty of Medicine, King Abdulaziz University, Jeddah, Saudi Arabia.ORCID http://orcid.org/0000-0001-6293-7497
Shimaa NassifDivision of Hematology/Oncology, The Hospital for Sick Children, Toronto, Ontario, Canada.
Nirav H ThackerDivision of Hematology/Oncology, The Hospital for Sick Children, Toronto, Ontario, Canada.
Tara FelthamDepartment of Pediatric Laboratory Medicine, The Hospital for Sick Children, Toronto, Ontario, Canada.
Noemi A Fuentes-BolanosChildren's Cancer Institute, Lowy Cancer Research Centre, UNSW Sydney, Kensington, New South Wales, Australia.
Marie Wong-ErasmusChildren's Cancer Institute, Lowy Cancer Research Centre, UNSW Sydney, Kensington, New South Wales, Australia.ORCID http://orcid.org/0000-0003-0066-6606
Max F LevineDepartment of Pediatrics, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Katherine E MillerThe Steve and Cindy Rasmussen Institute for Genomic Medicine, Nationwide Children's Hospital, Columbus, OH, USA.ORCID http://orcid.org/0000-0003-1054-0476
Neerav N ShuklaDepartment of Pediatrics, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Michael D KinnamanDepartment of Pediatrics, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Dominik GlodzikDepartment of Biomedical Informatics, Harvard Medical School, Boston, MA, USA.ORCID http://orcid.org/0000-0001-8112-9073
Carol PortwineDivision of Pediatric Hematology/Oncology, McMaster Children's Hospital, Hamilton, Ontario, Canada.
Sabrina MillsonDivision of Pediatric Hematology/Oncology, McMaster Children's Hospital, Hamilton, Ontario, Canada.
Alexandra P ZorziDepartment of Paediatrics, Children's Hospital at London Health Sciences Centre, London, Ontario, Canada.
Mariam MikhailDepartment of Paediatrics, Children's Hospital at London Health Sciences Centre, London, Ontario, Canada.
Conrad V FernandezDivision of Hematology-Oncology, IWK Health Centre, Halifax, Nova Scotia, Canada.ORCID http://orcid.org/0000-0002-0746-8306
Laura WheatonDepartment of Pediatrics, Queen's University, Kingston, Ontario, Canada.
Gunes GundemDepartment of Pediatrics, Memorial Sloan Kettering Cancer Center, New York, NY, USA.ORCID http://orcid.org/0000-0002-0070-9859
Andrew L KungDepartment of Pediatrics, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Uri TaboriArthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children, Toronto, Ontario, Canada.ORCID http://orcid.org/0000-0002-5019-2683
Chelsea MayohChildren's Cancer Institute, Lowy Cancer Research Centre, UNSW Sydney, Kensington, New South Wales, Australia.ORCID http://orcid.org/0000-0002-6398-3046
Elli PapaemmanuilDepartment of Pediatrics, Memorial Sloan Kettering Cancer Center, New York, NY, USA.ORCID http://orcid.org/0000-0003-1709-8983
Mark J CowleyChildren's Cancer Institute, Lowy Cancer Research Centre, UNSW Sydney, Kensington, New South Wales, Australia.ORCID http://orcid.org/0000-0002-9519-5714
David MalkinProgram in Genetics and Genome Biology, The Hospital for Sick Children, Toronto, Ontario, Canada.ORCID http://orcid.org/0000-0001-5752-9763
Anita VillaniDivision of Hematology/Oncology, The Hospital for Sick Children, Toronto, Ontario, Canada.
Ludmil B AlexandrovDepartment of Cellular and Molecular Medicine, University of California, San Diego, La Jolla, CA, USA.
Adam ShlienProgram in Genetics and Genome Biology, The Hospital for Sick Children, Toronto, Ontario, Canada. adam.shlien@sickkids.ca.ORCID http://orcid.org/0000-0002-0368-5370
Funding
No grant is acknowledged in the PubMed record.
Abstract
Children with cancer develop many short- and long-term side-effects of treatment
Indexed as
MutationNeoplasmsAntineoplastic AgentsChildDNA DamageHumansRecurrenceWhole Genome SequencingAntineoplastic Agents
Identifiers
What OpenQuestion holds
Textmetadata
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.