ArticleScientific reports2026
A dual-tier plasmid network model underpins the evolutionary success of pandemic Klebsiella pneumoniae ST11.
Article in Scientific reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
The convergence of antimicrobial resistance and hypervirulence in high-risk Klebsiella pneumoniae clones represents a major public health threat. However, evolutionary mechanisms enabling specific lineages to achieve pandemic dominance remain unclear. In this study, we integrated pangenomics and network analysis across 1,010 complete genomes from 38 countries. Species-wide dynamics revealed an extremely open pangenome (α = 0.59). In contrast, the dominant ST11 lineage, representing 30% of isolates, exhibited extremely low within-lineage phylogenetic diversity, consistent with a recent clonal expansion concentrated in East Asia. The East Asian ST11 lineage exhibited the lowest pangenome diversity (α = 0.86) associated with fixation of persistence and plasmid-stabilization systems and purging of redundant defense mechanisms. This configuration sustains a dual-tier plasmid network comprising a lineage-anchored IncFII(pHN7A8) replicon for vertical stability alongside high-connectivity hubs such as IncFIB(K) facilitating horizontal gene transfer. Chromosomal integration and tandem amplification of key resistance determinants (blaK
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