Evidence map›Paper›PMID 42486879›Full record

ArticleNature communications2026

Supramolecular nanofiber stabilization of microdroplets enables ultra-sensitive virus infection analysis.

Noriyuki Uchida, Atsuya Yaguchi, Shiori Kondo, Kazuyoshi Muranishi, Haruka Kawabata, Haruka Umezawa, Naito Ishimoto, Michiko Tajiri, Satoko Akashi, Takuya Seki and 13 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature communications, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

23 authors.

Noriyuki Uchida *Department of Applied Chemistry, Graduate School of Engineering, Tokyo University of Agriculture and Technology, Tokyo, Japan. n-uchida@go.tuat.ac.jp.
Atsuya Yaguchi *Department of Applied Chemistry, Graduate School of Engineering, Tokyo University of Agriculture and Technology, Tokyo, Japan.
Shiori Kondo *Department of Applied Chemistry, Graduate School of Engineering, Tokyo University of Agriculture and Technology, Tokyo, Japan.
Kazuyoshi MuranishiDepartment of Applied Chemistry, Graduate School of Engineering, Tokyo University of Agriculture and Technology, Tokyo, Japan.ORCID 0000-0001-9051-4854
Haruka KawabataDrug Design Laboratory, Graduate School of Medical Life Science, Yokohama City University, Yokohama, Japan.ORCID 0000-0001-7495-4219
Haruka UmezawaDrug Design Laboratory, Graduate School of Medical Life Science, Yokohama City University, Yokohama, Japan.ORCID 0009-0003-5055-0297
Naito IshimotoDrug Design Laboratory, Graduate School of Medical Life Science, Yokohama City University, Yokohama, Japan.ORCID 0000-0001-8976-8582
Michiko TajiriStructural Epigenetics Laboratory, Graduate School of Medical Life Science, Yokohama City University, Yokohama, Japan.ORCID 0000-0001-7017-7993
Satoko AkashiStructural Epigenetics Laboratory, Graduate School of Medical Life Science, Yokohama City University, Yokohama, Japan.
Takuya SekiDepartment of Physics, School of Science, Kitasato University, Sagamihara, Japan.
Go WatanabeDepartment of Physics, School of Science, Kitasato University, Sagamihara, Japan.ORCID 0000-0001-6713-1249
Ayano YoshidaDepartment of Applied Chemistry, Graduate School of Engineering, Tokyo University of Agriculture and Technology, Tokyo, Japan.
Genki HiguchiDepartment of Applied Chemistry, Graduate School of Engineering, Tokyo University of Agriculture and Technology, Tokyo, Japan.
Jakuei FuDepartment of Applied Chemistry, Graduate School of Engineering, Tokyo University of Agriculture and Technology, Tokyo, Japan.
Takanobu TakenouchiDepartment of Biomedical Engineering, Graduate School of Engineering, Tokyo University of Agriculture and Technology, Tokyo, Japan.
Daisuke YoshinoDepartment of Biomedical Engineering, Graduate School of Engineering, Tokyo University of Agriculture and Technology, Tokyo, Japan.
Hirotsugu HiramatsuDepartment of Applied Chemistry and Institute of Molecular Science, National Yang Ming Chiao Tung University, Hsinchu, Taiwan.ORCID 0000-0002-5239-3032
Masaki OkumuraFrontier Research Institute for Interdisciplinary Sciences, Tohoku University, Sendai, Japan.ORCID 0000-0001-8130-2470
Tomohide SaioDivision of Molecular Life Science, Institute of Advanced Medical Sciences, Tokushima University, Tokushima, Japan.ORCID 0000-0003-3639-7399
Hiroyuki NojiDepartment of Applied Chemistry, Graduate School of Engineering, The University of Tokyo, Tokyo, Japan.ORCID 0000-0002-8842-6836
Young-Ho LeeCenter for Protein Structure and Drug Mechanism Research, Korea Basic Science Institute (KBSI), Cheongju, Republic of Korea.ORCID 0000-0002-8441-5814
Sam-Yong ParkDrug Design Laboratory, Graduate School of Medical Life Science, Yokohama City University, Yokohama, Japan. park@yokohama-cu.ac.jp.ORCID 0000-0001-6164-8896
Takahiro MuraokaDepartment of Applied Chemistry, Graduate School of Engineering, Tokyo University of Agriculture and Technology, Tokyo, Japan. muraoka@go.tuat.ac.jp.ORCID 0000-0001-6744-048X

Funding

MEXT | Japan Science and Technology Agency (JST) JPMJAP2526MEXT | Japan Science and Technology Agency (JST) JPMJAX23DLMEXT | Japan Science and Technology Agency (JST) JPMJFR2122MEXT | Japan Science and Technology Agency (JST) JPMJFR244HMEXT | Japan Society for the Promotion of Science (JSPS) JP21H05096MEXT | Japan Society for the Promotion of Science (JSPS) JP23K04927MEXT | Japan Society for the Promotion of Science (JSPS) JP 25K01891MEXT | Japan Society for the Promotion of Science (JSPS) J-PEAKSMEXT | JST | Core Research for Evolutional Science and Technology (CREST) JPMJCR19S4Ministry of Education, Culture, Sports, Science and Technology (MEXT) JPMXP12 24UT0073New Energy and Industrial Technology Development Organization (NEDO) 23W1M041
6 · The paper itself

Abstract

Aqueous two-phase system (ATPS) droplets in cells act as fluidic microreactors by concentrating biomacromolecules. Inspired by this phenomenon, dextran-rich microdroplets formed in an ATPS with polyethylene glycol have been explored as artificial microreactors for sensitive detection and spatiotemporal control of biochemical reactions. However, the rapid fusion of the microdroplets into bulk phase separation has limited practical applications of this approach. Here, we report the stabilization of dextran-rich microdroplets using supramolecular nanofibers of an azobenzene-appending self-assembling peptide (AzSAP). Physicochemical characterization and structural analyses elucidate the mechanism of nanofiber formation and its role in droplet stabilization. The nanofiber network prevents droplet coalescence while maintaining macroscopic fluidity, thereby enabling highly sensitive quantitative virus detection via microfluidic analysis by confining infecting viruses within droplets. Furthermore, the photo-responsive properties of the AzSAP allow dynamic control over droplet size and intra-droplet virus activity, highlighting its exceptional potential as a platform for programmable artificial microreactors.

Indexed as

NanofibersAzo CompoundsDextransPeptidesPhase SeparationPolyethylene GlycolsazobenzeneAzo CompoundsDextransPeptidesPolyethylene Glycols

Identifiers

PMID42486879
PMCPMC13392239

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.