ArticleNan fang yi ke da xue xue bao = Journal of Southern Medical University2026
[MBD1 knockdown inhibits proliferation, migration and angiogenesis of human umbilical vein endothelial cells
Article in Nan fang yi ke da xue xue bao = Journal of Southern Medical University, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
objectivesTo investigate the effects of methyl-CpG binding domain protein 1 (MBD1) on proliferation, migration, and angiogenesis in human umbilical vein endothelial cells (HUVECs).
methodsCultured HUVECs were infected with a lentivirus carrying sh-MBD1 or a scramble shRNA (sh-NC), and the successfully infected cells were screened using puromycin. RT-qPCR and Western blotting were used to assess MBD1 gene silencing efficiency. The changes in proliferation, cell cycle, and migration of the infected cells were assessed using CCK-8 and colony formation assays, flow cytometry, scratch assay, and Transwell assay. The impact of MBD1 knockdown on angiogenic capacity of HUVECs was evaluated using angiogenesis assay. Immunofluorescence staining was used to investigate the expression of vascular endothelial growth factor A (VEGFA) in the infected HUVECs.
resultsCompared with the sh-NC cells, HUVECs infected with the lentivirus carrying sh-MBD1 exhibited significantly reduced proliferation capacity and migration ability. The total length of vessels formed
conclusionsMBD1 promotes proliferation, migration, and angiogenesis of HUVECs possibly by regulating the expression of VEGFA.
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