ArticleNan fang yi ke da xue xue bao = Journal of Southern Medical University2026
[Lonicera japonica attenuates oxidative stress and improves post-ischemic heart failure in mice
Article in Nan fang yi ke da xue xue bao = Journal of Southern Medical University, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
objectivesTo investigate the mechanism by which freeze-dried water extract of Lonicera japonica alleviates oxidative stress and improves post-ischemic heart failure in mice.
methodsBioinformatics analyses were carried out to identify the active constituents in Lonicera japonica, their target genes, and their enrichment pathways. Mouse models of ischemic heart failure established by left anterior descending (LAD) artery ligation were treated with different doses of freeze-dried water extract of Lonicera japonica, and the changes in cardiac function, myocardial pathology and expressions of the STAT3/PGC-1α axis were examined. In cultured H9C2 cells with oxygen-glucose deprivation (OGD), the effects of Lonicera japonica extract on cell viability, reactive oxygen species (ROS) production and apoptosis were evaluated, and its regulatory effects on STAT3 and PGC-1α expression were assessed using Western blotting and immunofluorescence staining; mass spectrometry was employed to analyze the tissue-penetrating components of Lonicera japonica extract, and the binding capacities of its major constituents to STAT3 and PGC-1α were simulated with molecular docking studies.
resultsIn mice with ischemic heart failure, treatment with Lonicera japonica extract significantly improved the cardiac function and alleviated myocardial hypertrophy, inflammatory responses and collagen deposition. The treatment also restored cell viability of H9C2 cells with OGD and reduced cellular ROS production and cell apoptosis. Lonicera japonica extract significantly inhibited STAT3 activation and upregulated PGC-1α expression in H9C2 cells with OGD, and this effect was effectively attenuated by application of the STAT3 agonist Colivelin. Molecular docking results suggested that among the components of Lonicera japonica extract capable of entering the myocardial tissues, lonicerin, chlorogenic acid and 1,5-dicaffeoylquinic acid had strong binding affinity with STAT3 and PGC-1α.
conclusionsLonicera japonica extract alleviates myocardial oxidative stress and improves heart failure in mice via the STAT3/PGC-1α axis, suggesting the value of Lonicera japonica in the treatment of heart failure.
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