ArticleNan fang yi ke da xue xue bao = Journal of Southern Medical University2026
[Chronic MRSA periprosthetic joint infection induces formation of mature tertiary lymphoid structures and osteolysis in mice].
Article in Nan fang yi ke da xue xue bao = Journal of Southern Medical University, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
objectivesTo investigate the histomorphological and functional characteristics of tertiary lymphoid structures (TLS) in a mouse model of chronic knee periprosthetic joint infection (PJI) with methicillin-resistant
methodsC57BL/6J mice receiving prosthesis implantation in the knee joint were randomized into control group and PJI group for injection of sterile PBS and of MRSA USA300 (1×10
resultsAt 21 days post-surgery, the mice in PJI group showed significant elevation of all the peripheral blood inflammatory markers. Numerous mature TLS were observed in the periprosthetic tissues in PJI group with an average cross-sectional area significantly greater than that in the control group. The TLS in PJI group exhibited a typical spatial organization, characterized by a B-cell-centered core surrounded by T cells with an FDC network; abundant Ki67-positive proliferating cells were observed within the TLS, and PNAd-positive high endothelial venules were visible at the periphery and within the parenchyma. The N.Oc/BS was significantly greater in PJI group than in the control group (28.75±4.13
conclusionsChronic MRSA infection induces formation of mature TLS with well-defined structural organization and functional activity in the periprosthetic region of mice, accompanied by significant bone loss.
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