Evidence map›Paper›PMID 42486390›Full record

ArticleAmerican journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons2026

Trending ileal microbiome dysbiosis over time as an early assessment of intestinal transplant rejection risk.

Julie S Hong, Abrar Shamim, Hussein Atta, Sarah Merl, Heekuk Park, Djamila Eliby, Alice Tillman, Mihir Tekal, Satyajit Patwardhan, Ishit Chauhan and 16 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

26 authors.

Julie S HongColumbia Center of Translational Immunology, Department of Medicine, Columbia University, New York, New York, USA.
Abrar ShamimColumbia Center of Translational Immunology, Department of Medicine, Columbia University, New York, New York, USA; College of Dental Medicine, Columbia University, New York, New York, USA.
Hussein AttaColumbia Center of Translational Immunology, Department of Medicine, Columbia University, New York, New York, USA.
Sarah MerlColumbia Center of Translational Immunology, Department of Medicine, Columbia University, New York, New York, USA.
Heekuk ParkDepartment of Infectious Diseases, Columbia University, New York, New York, USA.
Djamila ElibyDepartment of Infectious Diseases, Columbia University, New York, New York, USA.
Alice TillmanDepartment of Infectious Diseases, Columbia University, New York, New York, USA.
Mihir TekalColumbia Center of Translational Immunology, Department of Medicine, Columbia University, New York, New York, USA.
Satyajit PatwardhanColumbia Center of Translational Immunology, Department of Medicine, Columbia University, New York, New York, USA.
Ishit ChauhanColumbia Center of Translational Immunology, Department of Medicine, Columbia University, New York, New York, USA.
Philip JordacheColumbia Center of Translational Immunology, Department of Medicine, Columbia University, New York, New York, USA.
Bryan ChenColumbia Center of Translational Immunology, Department of Medicine, Columbia University, New York, New York, USA.
Ahmed AlmesallmyColumbia Center of Translational Immunology, Department of Medicine, Columbia University, New York, New York, USA.
M Esad GunesColumbia Center of Translational Immunology, Department of Medicine, Columbia University, New York, New York, USA.
Elin ManellColumbia Center of Translational Immunology, Department of Medicine, Columbia University, New York, New York, USA; Department of Clinical Sciences, Swedish University of Agricultural Sciences, Uppsala, Sweden.
Bo ShenDepartment of Surgery, Columbia University/New York-Presbyterian Hospital, New York, New York, USA.
Beatrice DionigiDepartment of Surgery, Columbia University/New York-Presbyterian Hospital, New York, New York, USA.
Ravi P KiranDepartment of Surgery, Columbia University/New York-Presbyterian Hospital, New York, New York, USA.
Steven B WellsDepartment of Microbiology and Immunology, Columbia University, New York, New York, USA.
Donna L FarberDepartment of Surgery, Columbia University/New York-Presbyterian Hospital, New York, New York, USA; Department of Microbiology and Immunology, Columbia University, New York, New York, USA.
Jianing FuColumbia Center of Translational Immunology, Department of Medicine, Columbia University, New York, New York, USA.
Tomoaki KatoColumbia Center of Translational Immunology, Department of Medicine, Columbia University, New York, New York, USA; Department of Surgery, Columbia University/New York-Presbyterian Hospital, New York, New York, USA.
Mercedes MartinezColumbia Center of Translational Immunology, Department of Medicine, Columbia University, New York, New York, USA; Department of Pediatrics, Columbia University, New York, New York, USA.
Ying Kuen CheungDepartment of Biostatistics, Columbia University, New York, New York, USA.
Anne-Catrin UhlemannDepartment of Infectious Diseases, Columbia University, New York, New York, USA.
Joshua WeinerColumbia Center of Translational Immunology, Department of Medicine, Columbia University, New York, New York, USA; Department of Surgery, Columbia University/New York-Presbyterian Hospital, New York, New York, USA. Electronic address: jiw2106@cumc.columbia.edu.

Funding

Training in Translational Immunology ResearchT32AI148099 · NIAID · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI SYKES, MEGAN · 2020 to 2024
$1.4M
Training Medical Students in NIDDK ResearchT35DK093430 · NIDDK · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI QAIS AL-AWQATI, Utpal Pajvani · 2012 to 2026
$1.3M
Defining the relationship between host-microbiome interactions and rejection after intestinal transplantationK23AI156026 · NIAID · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI WEINER, JOSHUA · 2021 to 2025
$962k
NIAID NIH HHS K23 AI156026NIAID NIH HHS T32 AI148099NIDDK NIH HHS T35 DK093430
6 · The paper itself

Abstract

Rejection is a barrier to intestinal transplantation (ITx). ITx rejection may be associated with changes in the ileal microbiome. We sought to analyze whether shifts in the microbiome were associated with intestinal transplant rejection. Ileal effluent samples were collected from ITx patients (n = 8) with multiple samples taken from each patient at times of no (n = 83), mild (n = 39), or moderate (n = 3) rejection, Crohn's disease (n = 20), and noninflamed control patients (n = 25). Ileal microbiota were quantified using 16S rRNA gene sequencing. Compared to nontransplant samples (noninflamed control, Crohn's disease), ITx samples had lower alpha diversity (Shannon and Chao1, P < .001) and different beta diversity (Bray-Curtis, P < .005). Beta diversity differed between samples with and without rejection (P = .002). Differential abundance analyses showed enrichment of pathogenic taxa and depletion of commensals in ITx rejection samples. ITx rejection is associated with ileal microbiome dysbiosis, which is a potential target for diagnostic and therapeutic interventions.

Indexed as

alpha diversitybeta diversityCrohn's diseaseintestinal transplantationmicrobiomerejectionrelative abundance

Identifiers

PMID42486390
PMCPMC13540342

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.