Evidence map›Paper›PMID 42486101›Full record

ArticleCell reports methods2026

Subtype-resolved norepinephrine imaging with an engineered α

Valentin Lu Rohner, Zacharoula Kagiampaki, Pauline Bohne, Antonia Renate Klein, Latife Sönmez, Laura Moreno Wasielewski, Musadiq A Bhat, Andreas Reiner, Melanie D Mark, Tommaso Patriarchi

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Article in Cell reports methods, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Valentin Lu RohnerInstitute of Pharmacology and Toxicology, University of Zürich, 8057 Zürich, Switzerland.
Zacharoula KagiampakiInstitute of Pharmacology and Toxicology, University of Zürich, 8057 Zürich, Switzerland.
Pauline BohneBehavioral Neuroscience, Ruhr University Bochum, 44801 Bochum, Germany.
Antonia Renate KleinBehavioral Neuroscience, Ruhr University Bochum, 44801 Bochum, Germany.
Latife SönmezCellular Neurobiology, Department of Biology and Biotechnology, Ruhr University Bochum, 44801 Bochum, Germany.
Laura Moreno WasielewskiCellular Neurobiology, Department of Biology and Biotechnology, Ruhr University Bochum, 44801 Bochum, Germany.
Musadiq A BhatInstitute of Pharmacology and Toxicology, University of Zürich, 8057 Zürich, Switzerland.
Andreas ReinerCellular Neurobiology, Department of Biology and Biotechnology, Ruhr University Bochum, 44801 Bochum, Germany.
Melanie D MarkBehavioral Neuroscience, Ruhr University Bochum, 44801 Bochum, Germany.
Tommaso PatriarchiInstitute of Pharmacology and Toxicology, University of Zürich, 8057 Zürich, Switzerland; Neuroscience Center Zurich, University and ETH Zürich, 8057 Zürich, Switzerland. Electronic address: patriarchi@pharma.uzh.ch.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Genetically encoded fluorescent indicators enable optical measurement of neuromodulator dynamics, but available norepinephrine (NE) sensors draw from a limited subset of adrenergic receptor scaffolds. Here, we developed Alpha1DLight, an NE indicator engineered from the human α

Indexed as

NorepinephrineProtein EngineeringReceptors, Adrenergic, alpha-1AnimalsHEK293 CellsHumansMiceNeuronsADRA1D protein, humanNorepinephrineReceptors, Adrenergic, alpha-1adrenergic receptorsCP: imagingCP: neuroscienceGPCRneuromodulatorsnorepinephrinepharmacologyreceptor subtype

Identifiers

PMID42486101
PMCPMC13615494

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.