Evidence map›Paper›PMID 42486080›Full record

ArticleMolecular cell2026

Nascent chain folding status modulates ribosome dynamics and mRNA stability through the ribosome-associated chaperone Zuo1.

Suhee Chang, Ryan Kawalerski, Mehmet Tardu, Sophie Martin, Kristin S Koutmou, Jeff Coller

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecular cell, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Suhee ChangDepartment of Molecular Biology and Genetics, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
Ryan KawalerskiDepartment of Molecular Biology and Genetics, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA; Department of Biomedical Engineering, Johns Hopkins University, Baltimore, MD 21218, USA.
Mehmet TarduDepartment of Biology, Istanbul University, Istanbul, Turkey.
Sophie MartinDepartment of Molecular Biology and Genetics, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
Kristin S KoutmouDepartment of Chemical Biology, University of Michigan, Ann Arbor, MI 48109, USA.
Jeff CollerDepartment of Molecular Biology and Genetics, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA; Department of Biomedical Engineering, Johns Hopkins University, Baltimore, MD 21218, USA; Institute for NanoBioTechnology, Johns Hopkins University, Baltimore, MD 21218, USA; RNA Innovation Center, Johns Hopkins University, Baltimore, MD 21218, USA. Electronic address: jmcoller@jhmi.edu.

Funding

Mechanisms of translational controlR35GM128836 · NIGMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Kristin S Koutmou · 2018 to 2026
$3.2M
Understanding the relationship between codon optimality and mRNA stabilityR35GM144114 · NIGMS · JOHNS HOPKINS UNIVERSITY · PI Jeffery Coller · 2022 to 2026
$3.0M
Investigating tRNA biology as a prognostic and oncogenic feature in pancreatic adenocarcinomaF30CA284534 · NCI · JOHNS HOPKINS UNIVERSITY · PI KAWALERSKI, RYAN · 2023 to 2025
$161k
NCI NIH HHS F30 CA284534NIGMS NIH HHS R35 GM128836NIGMS NIH HHS R35 GM144114
6 · The paper itself

Abstract

Ribosome dynamics during mRNA translation elongation regulate mRNA stability. Yet, known regulators of ribosome transit, such as codon usage, cannot fully explain transcriptome-wide decay rates. Here, we demonstrate that nascent polypeptide folding modulates elongation rates, with Zuotin (Zuo1) serving as an essential mediator. Using reporter constructs encoding co-translationally unstructured proteins and RNA sequencing under proteotoxic stress, we show that Zuo1 is required for selective destabilization of transcripts whose nascent peptides fail to fold properly. This process relies on the co-translational mRNA decay factor Not5, which detects slowed ribosomes.

Indexed as

Molecular ChaperonesPeptide Chain Elongation, TranslationalRibosomesRNA, FungalRNA, MessengerRNA StabilitySaccharomyces cerevisiaeSaccharomyces cerevisiae ProteinsGene Expression Regulation, FungalProtein BiosynthesisProtein FoldingProteotoxic StressRibosome ProfilingMolecular ChaperonesRNA, FungalRNA, MessengerSaccharomyces cerevisiae ProteinsZUO1 protein, S cerevisiaeelongation ratemRNA degradationmRNA stabilityNot5post-transcriptional regulationprotein chaperonesprotein foldingribosome speedZuo1

Identifiers

PMID42486080
PMCPMC13403997

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.