Evidence map›Paper›PMID 42486030›Full record

ArticlePoultry science2026

A yeast-based oral vaccine platform reveals antigen-dependent protection against Eimeria tenella.

Wenqi Han, Lang Chen, Lu Wang, Qiping Zhao, Shunhai Zhu, Yu Yu, Jiayu Bai, Hongyu Han, Lili Hao, Hui Dong

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Poultry science, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Wenqi HanShanghai Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Key Laboratory of Animal Parasitology of Ministry of Agriculture, Shanghai, 200241, PR China.
Lang ChenShanghai Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Key Laboratory of Animal Parasitology of Ministry of Agriculture, Shanghai, 200241, PR China; College of Animal Husbandry and Veterinary Medicine, Southwest Minzu University, Chengdu, 610041, PR China.
Lu WangShanghai Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Key Laboratory of Animal Parasitology of Ministry of Agriculture, Shanghai, 200241, PR China; Xin Hua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, 200241, PR China.
Qiping ZhaoShanghai Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Key Laboratory of Animal Parasitology of Ministry of Agriculture, Shanghai, 200241, PR China.
Shunhai ZhuShanghai Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Key Laboratory of Animal Parasitology of Ministry of Agriculture, Shanghai, 200241, PR China.
Yu YuShanghai Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Key Laboratory of Animal Parasitology of Ministry of Agriculture, Shanghai, 200241, PR China.
Jiayu BaiShanghai Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Key Laboratory of Animal Parasitology of Ministry of Agriculture, Shanghai, 200241, PR China.
Hongyu HanShanghai Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Key Laboratory of Animal Parasitology of Ministry of Agriculture, Shanghai, 200241, PR China.
Lili HaoCollege of Animal Husbandry and Veterinary Medicine, Southwest Minzu University, Chengdu, 610041, PR China.
Hui DongShanghai Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Key Laboratory of Animal Parasitology of Ministry of Agriculture, Shanghai, 200241, PR China. Electronic address: donghui@shvri.ac.cn.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The development of effective oral mucosal vaccines against intracellular enteric pathogens remains a formidable hurdle, demanding innovative platforms that combine targeted antigen delivery with the induction of potent local immunity. Avian coccidiosis, caused by Eimeria parasites, exemplifies this need, as its control is hampered by drug resistance and limitations of live vaccines. Here, we engineered a novel oral vaccine platform based on Saccharomyces cerevisiae surface display to deliver defined Eimeria tenella rhoptry antigens (EtRON2, its variants EtRON2

Indexed as

CoccidiosisEimeria tenellaMucosal immunityRhoptry antigenYeast surface display

Identifiers

PMID42486030
PMCPMC13392941

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.