ArticleBrazilian journal of otorhinolaryngology
Hsa-mir-1293/GLI1/PTCH1 axis is involved in proliferation, migration, and EMT of laryngeal cancer.
Article in Brazilian journal of otorhinolaryngology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveThis study aimed to investigate the specific role and molecular mechanisms of the transcription factor GLI1 and its upstream regulatory miRNA, hsa-mir-1293, in laryngeal cancer development, with a focus on elucidating the function of the hsa-mir-1293/GLI1/PTCH1 signaling axis in regulating laryngeal cancer cell proliferation, migration, and EMT.
methodsDifferentially expressed miRNAs were screened from TCGA laryngeal cancer miRNA data, and the interaction between hsa-mir-1293 and GLI1 was validated using a dual luciferase reporter assay. The effects of hsa-mir-1293 on TU212 cell proliferation, clonal formation, and invasion were examined. The role of GLI1's downstream target, PTCH1, in cell proliferation, migration, and EMT was further investigated.
resultsBioinformatics analysis identified hsa-mir-1293 as the most significantly down-regulated miRNA in laryngeal carcinoma, showing a negative correlation with GLI1 expression. Overexpression of hsa-mir-1293 suppressed TU212 cell proliferation, clonal formation, and invasion. Silencing GLI1 reduced PTCH1 expression, while PTCH1 overexpression promoted cell invasion, migration, and EMT.
conclusionHsa-mir-1293 targets GLI1, and the GLI1/PTCH1 axis plays a critical role in laryngeal cancer cell proliferation, migration, and EMT. LEVEL OF EVIDENCE: 5:
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.